Shi Tang, Qing Liu, Mingcheng Song, Xiangshuai Li, Degang Ji, Ying-Wei Yang, Huimei Yu
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A silica nanobean carrier utilizing lysosomal and mitochondrial autophagy to kill ovarian cancer cell
The development of responsive and smart drug nanocarriers that defeat the tumor microenvironment that resists cancer therapy has attracted considerable attention in recent decades. Upgrades are sought to effectively increase the therapeutic efficacy of chemotherapy drugs and reduce damage to normal tissues. In this study, a new type of silica nano-particle carrier, dual-functionalized mesoporous silica nanobeans (DF-MSNB), is used to encapsulate the drug, doxorubicin (DOX), to form the DOX@DF-MSNB complex. The complex simultaneously releases drugs and tracks drug uptake by cells after the environmentally triggered release of the encapsulated drug and fluorophore. Upon sensing the high GSH level and low pH in the tumor microenvironment, the disulfide bond breaks in the linker between the drug and the carrier. An attached fluorescent group is activated, and the DOX drug is released from the carrier. Our results show that DOX@DF-MSNB co-localizes with mitochondria and lysosomes in A2780 cells, enabling DOX to subvert the cells’ mitochondrial function and activate macrophage and mitochondrial autophagy. The application of a mitochondrial autophagy inhibitor confirms that DOX@DF-MSNB inhibits tumor development by activating mitochondrial autophagy.
期刊介绍:
APL Materials features original, experimental research on significant topical issues within the field of materials science. In order to highlight research at the forefront of materials science, emphasis is given to the quality and timeliness of the work. The journal considers theory or calculation when the work is particularly timely and relevant to applications.
In addition to regular articles, the journal also publishes Special Topics, which report on cutting-edge areas in materials science, such as Perovskite Solar Cells, 2D Materials, and Beyond Lithium Ion Batteries.