碳点和碲化镉量子点对黑腹果蝇毒性的比较

IF 3.5 Q3 ENGINEERING, ENVIRONMENTAL
Shawninder Chahal, Jun-Ray Macairan, Hoai-Nam N. Bui, Anthony Smith, Hans C. E. Larsson, Rafik Naccache and Nathalie Tufenkji
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引用次数: 0

摘要

碳点(CD)是一种碳纳米粒子,尺寸通常在 10 纳米以下,具有许多类似于量子点(QD)的特性。碲化镉量子点(CdTeQDs)是一种经常被研究的量子点,因为它们的尺寸和荧光光谱都很容易控制。然而,众所周知,镉是有毒的,因此许多国家限制或完全禁止在消费品中使用镉。虽然许多研究都考察了 CD 和 CdTeQDs 的毒性,但很少有研究在相同条件下直接比较这两种纳米粒子。在此,我们直接比较了掺氮 CD(NCD)、氮硫共掺 CD(SCD)和 CdTeQDs 在模式生物黑腹果蝇(果蝇)体内的毒性。在 10 - 100 毫克/千克的食物范围内,未观察到 NCDs 或 SCDs 对幼虫发育成成虫的影响,而食物中 CdTeQDs 的 EC50 值为 46 毫克/千克。研究发现,食物中的镉碲齐丁二烯浓度与平均化蛹和羽化时间之间存在很强的正相关性,表明随着镉碲齐丁二烯浓度的增加,发育会严重滞后。亚致死浓度下的进一步实验表明,在评估繁殖性能、幼虫爬行能力和苍蝇攀爬能力时,任何处理之间都没有显著差异。对照组和处理组苍蝇的肠管解剖结构确实存在差异,所有处理组个体的中肠都被拉长,在某些情况下,中肠还被撑大。这项研究表明,在 10-100 mg kg-1 的食物范围内,NCDs 和 SCDs 的毒性都比 CdTeQDs 低得多,这进一步推动了前者在生物相容性 QD 类纳米材料中的潜在应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

A comparison of carbon dot and CdTe quantum dot toxicity in Drosophila melanogaster†

A comparison of carbon dot and CdTe quantum dot toxicity in Drosophila melanogaster†

A comparison of carbon dot and CdTe quantum dot toxicity in Drosophila melanogaster†

Carbon dots (CDs) are carbon nanoparticles that are typically ∼10 nm in size and feature many properties similar to quantum dots (QDs). Cadmium telluride QDs (CdTeQDs) are a frequently studied QD since their size, and therefore fluorescence spectra, can be easily controlled. However, cadmium is known to be toxic, making its use in consumer goods limited or outright banned in many jurisdictions. While many studies have examined the toxicity of CDs and CdTeQDs, few have directly compared both nanoparticles under the same conditions. Herein, we provide a direct comparison of the toxicity of nitrogen-doped CDs (NCDs), nitrogen, sulfur co-doped CDs (SCDs), and CdTeQDs in the model organism Drosophila melanogaster (fruit fly). No impact on the development of larvae into adult flies from NCDs or SCDs in the 10 – 100 mg kg−1 food range was observed, whereas an EC50 of 46 mg kg−1 CdTeQDs in food was observed. A strong positive correlation was found between the concentration of CdTeQDs in food and the mean pupation and eclosion time, indicating severe developmental delays as CdTeQD concentration increased. Further experiments at sublethal concentrations revealed no significant difference between any of the treatments when evaluating reproductive performance, larval crawling, and fly climbing ability. Gut tube anatomy did differ between control and treatment flies, with all treatment individuals expressing lengthened, and in some cases, distended midguts. This work demonstrates that both NCDs and SCDs are considerably less toxic than CdTeQDs in the 10–100 mg kg−1 food range, further enabling the former's potential applications for biocompatible QD-like nanomaterials.

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