高强度太赫兹辐射对人类神经祖细胞分化的影响

IF 0.8 4区地球科学 Q4 ENGINEERING, ELECTRICAL & ELECTRONIC

Radiophysics and Quantum Electronics Pub Date : 2024-05-11 DOI:10.1007/s11141-024-10321-y

D. S. Sitnikov, V. A. Revkova, I. V. Ilina, R. O. Shatalova, M. A. Konoplyannikov, V. A. Kalsin, V. P. Baklaushev

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引用次数: 0

摘要

我们展示了高强度太赫兹脉冲对诱导人类神经祖细胞（drNPCs）分化影响的研究结果。通过免疫细胞化学分析，即未分化细胞的标记物（SOX2）以及神经元（β-III-tubulin 和 MAP2b）和胶质细胞（GFAP）表型的标记物，对分化情况进行了估计。细胞暴露是通过强度为 21 GW/cm2 的太赫兹脉冲和 2.8 MV/cm 的电场进行的，持续时间为 30 分钟。暴露后，诱导的神经祖细胞的表型与未暴露细胞的表型没有区别，也没有检测到成熟神经元或神经胶质细胞的出现。太赫兹辐射能否对神经细胞培养产生影响，显然还需要对更高的辐射强度或持续时间进行进一步研究。

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Influence of High-Intensity Terahertz Radiation on the Differentiation of Human Neural Progenitor Cells

We present the results of studying the impact of high-intensity terahertz pulses on the differentiation of induced human neural progenitor cells (drNPCs). The differentiation was estimated using the immunocytochemical analysis, i.e., the marker of the undifferentiated cells (SOX2) and the markers of the neuronal (β-III-tubulin and MAP2b) and glial (GFAP) phenotype. The cell exposure was performed by terahertz pulses with an intensity of 21 GW/cm² and an electric field of 2.8 MV/cm for 30 min. As a result of exposure, the phenotype of induced neural progenitor cells did not differ from that of unexposed cells and the appearance of mature neurons or glial cells was not detected. The ability of the terahertz radiation to cause effects in neural cell cultures apparently requires further studies for higher exposure intensity or duration.

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来源期刊

Radiophysics and Quantum Electronics ENGINEERING, ELECTRICAL & ELECTRONIC-PHYSICS, APPLIED

CiteScore

1.10

自引率

12.50%

发文量

审稿时长

6-12 weeks

期刊介绍： Radiophysics and Quantum Electronics contains the most recent and best Russian research on topics such as: Radio astronomy; Plasma astrophysics; Ionospheric, atmospheric and oceanic physics; Radiowave propagation; Quantum radiophysics; Pphysics of oscillations and waves; Physics of plasmas; Statistical radiophysics; Electrodynamics; Vacuum and plasma electronics; Acoustics; Solid-state electronics. Radiophysics and Quantum Electronics is a translation of the Russian journal Izvestiya VUZ. Radiofizika, published by the Radiophysical Research Institute and N.I. Lobachevsky State University at Nizhnii Novgorod, Russia. The Russian volume-year is published in English beginning in April. All articles are peer-reviewed.