Adverse events with endoscopic ultrasound-guided gastroenterostomy for gastric outlet obstruction-A systematic review and meta-analysis.

Background: The technical and clinical effectiveness of endoscopic ultrasonography (EUS)-guided gastroenterostomy (GE) has been reported by several meta-analyses, but few of them have addressed the adverse events (AE). The goal of the current meta-analysis was to analyze the AEs associated with various types of EUS-GE.

Methods: All relevant studies reporting the AEs with EUS-GE were searched from 2000 to 31st March 2023 in MEDLINE, Embase, and Scopus. The event rates were pooled using a random effects model.

Results: A total of 36 studies (n = 1846) were included in the meta-analysis. The present meta-analysis reports a pooled technical success rate of 96.9% (95.9-98.0; I² = 29.3%) with a pooled clinical success rate of 90.6% (88.5-92.7; I² = 60.9%). The pooled incidence of overall AEs with EUS-GE was 13.0% (10.3-15.7; I² = 69.7%), with the commonest being maldeployment of the stent, seen in 4.6% (3.2-6.0; I² = 50.6%). The pooled incidences of serious AE and procedure-related mortality were 1.2% (0.7-1.8; I² = 1.9%) and 0.3% (0.0-0.7; I² = 0.0%), respectively. Subgroup analysis of studies using only the free-hand technique showed a significantly lower overall AE and maldeployment but not serious AE and other individual AEs. The pooled incidences of delayed stent migration and stent occlusion were 0.5% (0.0-1.1; I² = 0.0%) and 0.8% (0.2-1.3; I² = 0.0%), respectively.

Conclusion: Despite a technical and clinical success rate of >90%, AEs are seen in around one-seventh of the cases of EUS-GE, maldeployment being the commonest. However, the pooled incidence of serious AE and mortality remains low, which is reassuring.