在成年小鼠的前扣带回皮层中,福斯可林对皮层无声反应的诱导作用。

IF 2.8 3区 医学 Q2 NEUROSCIENCES
Yujie Ma, Jinjin Wan, Shun Hao, Qi-Yu Chen, Min Zhuo
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引用次数: 0

摘要

最近采用不同实验方法进行的研究表明,成人大脑皮层(包括感觉皮层和前扣带回皮层(ACC))中可能存在沉默突触。ACC 中的突触后长期电位(LTP)形式会招募其中一些沉默突触,而这种招募需要钙刺激腺苷酸环化酶(ACs)的活性。目前还不知道化学激活 ACs 是否会招募沉默突触。在这项研究中,我们发现 ACs 的激活有助于成年小鼠 ACC 的突触增效。福斯可林是一种选择性 ACs 激活剂,它能招募成年小鼠 ACC 中的沉默反应。这种激活是持久的。有趣的是,福斯可林的作用并不普遍,一些无声突触并没有发生电位增强或招募。这些发现表明,这些成年大脑皮层突触并不是同质的。应用选择性钙离子渗透 AMPA 受体抑制剂 1-萘乙酰精胺(NASPM)可逆转沉默反应的电位增强和招募,这表明 AMPA 受体是必需的。我们的研究结果有力地表明,依赖于AC的突触后AMPA受体有助于在大脑皮层LTP中招募沉默反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Recruitment of cortical silent responses by forskolin in the anterior cingulate cortex of adult mice.

Recent studies using different experimental approaches demonstrate that silent synapses may exist in the adult cortex including the sensory cortex and anterior cingulate cortex (ACC). The postsynaptic form of long-term potentiation (LTP) in the ACC recruits some of these silent synapses and the activity of calcium-stimulated adenylyl cyclases (ACs) is required for such recruitment. It is unknown if the chemical activation of ACs may recruit silent synapses. In this study, we found that activation of ACs contributed to synaptic potentiation in the ACC of adult mice. Forskolin, a selective activator of ACs, recruited silent responses in the ACC of adult mice. The recruitment was long-lasting. Interestingly, the effect of forskolin was not universal, some silent synapses did not undergo potentiation or recruitment. These findings suggest that these adult cortical synapses are not homogenous. The application of a selective calcium-permeable AMPA receptor inhibitor 1-naphthyl acetyl spermine (NASPM) reversed the potentiation and the recruitment of silent responses, indicating that the AMPA receptor is required. Our results strongly suggest that the AC-dependent postsynaptic AMPA receptor contributes to the recruitment of silent responses at cortical LTP.

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来源期刊
Molecular Pain
Molecular Pain 医学-神经科学
CiteScore
5.60
自引率
3.00%
发文量
56
审稿时长
6-12 weeks
期刊介绍: Molecular Pain is a peer-reviewed, open access journal that considers manuscripts in pain research at the cellular, subcellular and molecular levels. Molecular Pain provides a forum for molecular pain scientists to communicate their research findings in a targeted manner to others in this important and growing field.
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