吸入皮质类固醇对 COVID-19 死亡率的影响：随机对照试验的系统回顾和荟萃分析。

IF 2.5 4区医学 Q1 MEDICINE, GENERAL & INTERNAL

Journal of Investigative Medicine Pub Date : 2024-08-01 Epub Date: 2024-05-15 DOI:10.1177/10815589241249997

Fen Yang, Guizuo Wang, Dong Han

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引用次数: 0

摘要

本系统综述和荟萃分析旨在确定吸入性皮质类固醇（ICS）对冠状病毒病-2019（COVID-19）患者死亡率的疗效。我们在PubMed、Embase、Cochrane Library和clinicaltrials.gov上进行了系统检索，没有语言限制。对使用 ICS 治疗 COVID-19 的随机对照试验（RCT）进行了审查。研究结果汇总为风险比 (RRs)，以及 95% 置信区间 (CIs)。有 11 项 RCT（共 5832 人参与）符合纳入标准。两组患者在 COVID-19 相关死亡（RR 0.88，95% CI 0.38-2.04）、全因死亡（RR 1.05，95% CI 0.49-2.23）和侵入性通气（RR 1.26，95% CI 0.60-2.62）方面均无明显统计学差异。ICS与COVID-19患者死亡率和有创通气的减少无关。

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Inhaled corticosteroids on mortality in COVID-19: A systematic review and meta-analysis of randomized controlled trials.

This systematic review and meta-analysis aimed to determine the efficacy of inhaled corticosteroids (ICS) on mortality in patients with coronavirus disease-2019 (COVID-19). A systematic search was made of PubMed, Embase, Cochrane Library, and clinicaltrials.gov, without language restrictions. Randomized controlled trials (RCTs) on the treatment of COVID-19 with ICS were reviewed. Studies were pooled to risk ratios (RRs), with 95% confidence intervals (CIs). Eleven RCTs (enrolling 5832 participants) met the inclusion criteria. There was no statistically significant difference in COVID-19-related death (RR 0.88, 95% CI 0.38-2.04), all-cause death (RR 1.05, 95% CI 0.49-2.23), and invasive ventilation (RR 1.26, 95% CI 0.60-2.62) between the two groups. ICS was not associated with reduced mortality and invasive ventilation in patients with COVID-19.

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来源期刊

Journal of Investigative Medicine 医学-医学：内科

CiteScore

4.90

自引率

0.00%

发文量

111

审稿时长

24 months

期刊介绍： Journal of Investigative Medicine (JIM) is the official publication of the American Federation for Medical Research. The journal is peer-reviewed and publishes high-quality original articles and reviews in the areas of basic, clinical, and translational medical research. JIM publishes on all topics and specialty areas that are critical to the conduct of the entire spectrum of biomedical research: from the translation of clinical observations at the bedside, to basic and animal research to clinical research and the implementation of innovative medical care.