一名免疫力低下的成年患者体内的 SARS-CoV-2 脱落、传染性和演变。

IF 1.5 4区医学 Q4 INFECTIOUS DISEASES

Revista Do Instituto De Medicina Tropical De Sao Paulo Pub Date : 2024-05-13 eCollection Date: 2024-01-01 DOI:10.1590/S1678-9946202466028

Maria Cassia Mendes-Correa, Fábio de Rose Ghilardi, Matias Chiarastelli Salomão, Lucy Santos Villas-Boas, Anderson Vicente de Paula, Heuder Gustavo Oliveira Paiao, Antonio Charlys da Costa, Tânia Regina Tozetto-Mendoza, Wilton Freire, Flavia Cristina Silva Sales, Ingra Morales Claro, Ester Cerdeira Sabino, Nuno Rodrigues Faria, Steven Sol Witkin

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引用次数: 0

摘要

本研究旨在通过分析一名曾因弥漫大 B 细胞淋巴瘤接受过自体造血干细胞移植的 40 岁男子的病例，进一步了解 SARS-CoV-2 的进化动态。他持续感染 SARS-CoV-2 至少 218 天，在随访期间没有表现出对病毒的体液免疫反应。全基因组测序和病毒培养证实，他持续感染了一种复制阳性病毒，该病毒在症状出现后至少 196 天内发生了基因变异。

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SARS-CoV-2 shedding, infectivity, and evolution in an immunocompromised adult patient.

This study aimed to provide further insight into the evolutionary dynamics of SARS-CoV-2 by analyzing the case of a 40-year-old man who had previously undergone autologous hematopoietic stem cell transplantation due to a diffuse large B-cell lymphoma. He developed a persistent SARS-CoV-2 infection lasting at least 218 days and did not manifest a humoral immune response to the virus during this follow-up period. Whole-genome sequencing and viral cultures confirmed a persistent infection with a replication-positive virus that had undergone genetic variation for at least 196 days after symptom onset.

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来源期刊

Revista Do Instituto De Medicina Tropical De Sao Paulo TROPICAL MEDICINE-

CiteScore

3.60

自引率

5.30%

发文量

100

审稿时长

6-12 weeks

期刊介绍： The Revista do Instituto de Medicina Tropical de São Paulo (Journal of the São Paulo Institute of Tropical Medicine) is a journal devoted to research on different aspects of tropical infectious diseases. The journal welcomes original work on all infectious diseases, provided that data and results are directly linked to human health. The journal publishes, besides original articles, review articles, case reports, brief communications, and letters to the editor. The journal publishes manuscripts only in English. From 2016 on, the Revista do Instituto de Medicina Tropical de São Paulo (Journal of the São Paulo Institute of Tropical Medicine) is published online only, maintaining the free access. For more information visit: - http://www.scielo.br/rimtsp - http://www.imt.usp.br/revista-imt/