哥伦比亚亚马逊国际边境地区发现的首例奥罗普切热：临床特征和分子诊断。

IF 2.5 4区医学 Q2 PARASITOLOGY

Memorias do Instituto Oswaldo Cruz Pub Date : 2024-05-13 eCollection Date: 2024-01-01 DOI:10.1590/0074-02760230221

Juan Camilo Grisales-Nieto, Sérgio Luiz Bessa Luz, Valdinete Alves do Nascimento, Felipe Gomes Naveca, Luz Mila Murcia-Montaño, Kelly Natalia Romero-Vesga, Olga Eshter Bellido-Cuellar, José Joaquín Carvajal-Cortés

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引用次数: 0

摘要

目的：我们报告了在哥伦比亚边境地区发现的首例奥罗普切热病例：我们报告了在哥伦比亚边境地区发现的首例奥罗普切热病例：利用多重实时聚合酶链反应（PCR）、基因测序和 2019 年登革热疫情期间的临床特征，对向登革热等流行病学监测系统通报的病例中的 175 份样本进行了分析：根据 M 和 S 基因组片段最大似然法（ML）分析，莱蒂西亚的奥罗普切病毒（OROV）分离株属于第 2 系，与厄瓜多尔埃斯梅拉达斯和哥伦比亚图尔瓦科的样本具有共同祖先。患者：一名居住在莱蒂西亚市边境居民区的妇女，有以下症状：发烧、头痛、眶后疼痛和肌痛：主要结论：这种跨境监测有助于提醒人们注意该地区虫媒病毒的出入境情况，而公共卫生监测系统对这些情况往往报告不足。

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First case of Oropouche fever detected in the international border region of the Colombian Amazon: clinical characteristics and molecular diagnosis.

Objectives: We report the first case of Oropouche fever detected in the border region of Colombia.

Methods: Using a multiplex real-time polymerase chain reaction (PCR), genetic sequencing and clinical characteristics during the dengue epidemic in 2019, a total of 175 samples were analysed, from cases notified to the system epidemiological surveillance such as dengue.

Findings: The Oropouche virus (OROV) isolate from Leticia belongs to lineage 2 according to both M and S genome segments maximum likelihood (ML) analysis, shares a common ancestor with samples obtained in Esmeraldas, Ecuador and Turbaco, Colombia. The patient: a woman resident in the border neighbourhood of the municipality of Leticia had the following symptoms: fever, headache, retro-orbital pain and myalgias.

Main conclusion: This cross-border surveillance can be useful to give an alert about the entry or exit of arboviruses circulation in the region, which are often underreported in public health surveillance systems.

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来源期刊

Memorias do Instituto Oswaldo Cruz 医学-寄生虫学

CiteScore

5.00

自引率

3.60%

发文量

审稿时长

3-8 weeks

期刊介绍： Memórias do Instituto Oswaldo Cruz is a journal specialized in microbes & their vectors causing human infections. This means that we accept manuscripts covering multidisciplinary approaches and findings in the basic aspects of infectious diseases, e.g. basic in research in prokariotes, eukaryotes, and/or virus. Articles must clearly show what is the main question to be answered, the hypothesis raised, and the contribution given by the study. Priority is given to manuscripts reporting novel mechanisms and general findings concerning the biology of human infectious prokariotes, eukariotes or virus. Papers reporting innovative methods for diagnostics or that advance the basic research with these infectious agents are also welcome. It is important to mention what we do not publish: veterinary infectious agents research, taxonomic analysis and re-description of species, epidemiological studies or surveys or case reports and data re-analysis. Manuscripts that fall in these cases or that are considered of low priority by the journal editorial board, will be returned to the author(s) for submission to another journal.