内溶酶体系统中的 PROPPINs 和膜裂变。

IF 3.8 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Navin Gopaldass, Andreas Mayer
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引用次数: 0

摘要

PROPPINs 是一个保守的蛋白质家族,其多个成员在许多真核生物中都有表达。人们主要研究了 PROPPINs 在自噬过程中的作用,它们与自噬体形成过程中的几个核心因子合作。最近,人们发现了这些蛋白在内含溶酶体区室中的新功能。PROPPINs 支持这些细胞器的分裂,并支持形成管泡货物载体,从而介导蛋白质从这些细胞器中排出,例如由 Retromer 衣壳产生的载体。在这两种情况下,PROPPINs 都具有膜分裂活性。本综述综合了酵母和人类细胞的信息,总结了这些蛋白质促进膜裂解的最重要的分子特征,从而为内溶酶体蛋白质的运输提供了一个关键因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
PROPPINs and membrane fission in the endo-lysosomal system.

PROPPINs constitute a conserved protein family with multiple members being expressed in many eukaryotes. PROPPINs have mainly been investigated for their role in autophagy, where they co-operate with several core factors for autophagosome formation. Recently, novel functions of these proteins on endo-lysosomal compartments have emerged. PROPPINs support the division of these organelles and the formation of tubulo-vesicular cargo carriers that mediate protein exit from them, such as those generated by the Retromer coat. In both cases, PROPPINs provide membrane fission activity. Integrating information from yeast and human cells this review summarizes the most important molecular features that allow these proteins to facilitate membrane fission and thus provide a critical element to endo-lysosomal protein traffic.

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来源期刊
Biochemical Society transactions
Biochemical Society transactions 生物-生化与分子生物学
CiteScore
7.80
自引率
0.00%
发文量
351
审稿时长
3-6 weeks
期刊介绍: Biochemical Society Transactions is the reviews journal of the Biochemical Society. Publishing concise reviews written by experts in the field, providing a timely snapshot of the latest developments across all areas of the molecular and cellular biosciences. Elevating our authors’ ideas and expertise, each review includes a perspectives section where authors offer comment on the latest advances, a glimpse of future challenges and highlighting the importance of associated research areas in far broader contexts.
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