通过 AS03ation 获得免疫力：天然佐剂

IF 25.5 1区医学 Q1 IMMUNOLOGY

Immunity Pub Date : 2024-05-14 DOI:10.1016/j.immuni.2024.04.011

Lena Hansen, Jenna J. Guthmiller

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引用次数: 0

摘要

人类对疫苗接种的反应不尽相同。为了探究其中的原因，Mulè 等人开发了一个多模式框架，发现在接种无佐剂流感疫苗后，高抗体应答者处于自然佐剂状态，模仿接种 AS03 佐剂疫苗后的先天免疫表型。这突显了区分高抗体应答者的生物因素，以及佐剂如何增强先天免疫线索以改善体液免疫。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Immunity by AS03ation: The natural adjuvantage

Humans do not respond equally to vaccination. To investigate why, Mulè et al. developed a multimodal framework and found that high responders after unadjuvanted influenza vaccination exist in a naturally adjuvanted state, mimicking innate immunophenotypes following AS03-adjuvanted vaccination. This highlights biological factors that set apart high-antibody responders and how adjuvants can boost innate immune cues to improve humoral immunity.

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来源期刊

Immunity 医学-免疫学

CiteScore

49.40

自引率

2.20%

发文量

205

审稿时长

6 months

期刊介绍： Immunity is a publication that focuses on publishing significant advancements in research related to immunology. We encourage the submission of studies that offer groundbreaking immunological discoveries, whether at the molecular, cellular, or whole organism level. Topics of interest encompass a wide range, such as cancer, infectious diseases, neuroimmunology, autoimmune diseases, allergies, mucosal immunity, metabolic diseases, and homeostasis.