Rirong Chen , Yue Li , Na Zhang , Lingling Zhang , Peiliang Zhang , Tao Wu
{"title":"从 Nelumbo nucifera Gaertn 花蕊中提取的具有单、双和三棕榈酰链的消炎齐墩果烷三萜类化合物","authors":"Rirong Chen , Yue Li , Na Zhang , Lingling Zhang , Peiliang Zhang , Tao Wu","doi":"10.1016/j.indcrop.2024.118698","DOIUrl":null,"url":null,"abstract":"<div><p>Ten undescribed compounds were isolated from the stamen of <em>Nelumbo nucifera</em> Gaertn., including seven oleanane triterpenoid glycosides with 1<strong>–</strong>3 palmitoyl chains (<strong>1</strong>–<strong>7</strong>), an oleanane triterpenoid aglycon (<strong>8</strong>), and two degraded cycloartane triterpenoids (<strong>9</strong> and <strong>10</strong>). In addition, seven known oleanane triterpenoids (<strong>11</strong>–<strong>17</strong>) were isolated. Among these compounds, <strong>9</strong> was an artificial and <strong>14</strong> was novel and natural product. The anti-inflammatory activity of the 10 undescribed compounds was evaluated by analyzing their inhibitory effects on the release of NO in LPS-induced RAW264.7 macrophages. Nelmnucifergenin A (<strong>8</strong>) and nelmnucifergenin B (<strong>9</strong>) showed the maximum inhibitory effects with IC<sub>50</sub> values of 16.79 and 20.78 μM, respectively. Additionally, they inhibited the production of TNF-<em>α</em> and IL-6 and down-regulated the key inflammation-related enzymes (iNOS and COX-2).</p></div>","PeriodicalId":13581,"journal":{"name":"Industrial Crops and Products","volume":"216 ","pages":"Article 118698"},"PeriodicalIF":6.2000,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Anti-inflammatory oleanane triterpenoids with mono-, di-, and tri-palmitoyl chains from the stamen of Nelumbo nucifera Gaertn\",\"authors\":\"Rirong Chen , Yue Li , Na Zhang , Lingling Zhang , Peiliang Zhang , Tao Wu\",\"doi\":\"10.1016/j.indcrop.2024.118698\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Ten undescribed compounds were isolated from the stamen of <em>Nelumbo nucifera</em> Gaertn., including seven oleanane triterpenoid glycosides with 1<strong>–</strong>3 palmitoyl chains (<strong>1</strong>–<strong>7</strong>), an oleanane triterpenoid aglycon (<strong>8</strong>), and two degraded cycloartane triterpenoids (<strong>9</strong> and <strong>10</strong>). In addition, seven known oleanane triterpenoids (<strong>11</strong>–<strong>17</strong>) were isolated. Among these compounds, <strong>9</strong> was an artificial and <strong>14</strong> was novel and natural product. The anti-inflammatory activity of the 10 undescribed compounds was evaluated by analyzing their inhibitory effects on the release of NO in LPS-induced RAW264.7 macrophages. Nelmnucifergenin A (<strong>8</strong>) and nelmnucifergenin B (<strong>9</strong>) showed the maximum inhibitory effects with IC<sub>50</sub> values of 16.79 and 20.78 μM, respectively. Additionally, they inhibited the production of TNF-<em>α</em> and IL-6 and down-regulated the key inflammation-related enzymes (iNOS and COX-2).</p></div>\",\"PeriodicalId\":13581,\"journal\":{\"name\":\"Industrial Crops and Products\",\"volume\":\"216 \",\"pages\":\"Article 118698\"},\"PeriodicalIF\":6.2000,\"publicationDate\":\"2024-05-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Industrial Crops and Products\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0926669024006757\",\"RegionNum\":1,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"AGRICULTURAL ENGINEERING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Industrial Crops and Products","FirstCategoryId":"97","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0926669024006757","RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"AGRICULTURAL ENGINEERING","Score":null,"Total":0}
Anti-inflammatory oleanane triterpenoids with mono-, di-, and tri-palmitoyl chains from the stamen of Nelumbo nucifera Gaertn
Ten undescribed compounds were isolated from the stamen of Nelumbo nucifera Gaertn., including seven oleanane triterpenoid glycosides with 1–3 palmitoyl chains (1–7), an oleanane triterpenoid aglycon (8), and two degraded cycloartane triterpenoids (9 and 10). In addition, seven known oleanane triterpenoids (11–17) were isolated. Among these compounds, 9 was an artificial and 14 was novel and natural product. The anti-inflammatory activity of the 10 undescribed compounds was evaluated by analyzing their inhibitory effects on the release of NO in LPS-induced RAW264.7 macrophages. Nelmnucifergenin A (8) and nelmnucifergenin B (9) showed the maximum inhibitory effects with IC50 values of 16.79 and 20.78 μM, respectively. Additionally, they inhibited the production of TNF-α and IL-6 and down-regulated the key inflammation-related enzymes (iNOS and COX-2).
期刊介绍：
Industrial Crops and Products is an International Journal publishing academic and industrial research on industrial (defined as non-food/non-feed) crops and products. Papers concern both crop-oriented and bio-based materials from crops-oriented research, and should be of interest to an international audience, hypothesis driven, and where comparisons are made statistics performed.
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