模式识别受体与免疫代谢重编程:我们的认知与探索。

IF 4.7 3区 医学 Q2 IMMUNOLOGY
Journal of Innate Immunity Pub Date : 2024-01-01 Epub Date: 2024-05-13 DOI:10.1159/000539278
Vijay Kumar, John H Stewart Iv
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引用次数: 0

摘要

背景:在进化过程中,免疫反应是一种保护宿主免受内外威胁的复杂机制。模式识别受体(PRRs)能识别 MAMPs、PAMPs 和 DAMPs,从而启动保护性促炎免疫反应。TLR1、2、4 和 6 在细胞膜上表达 PRRs,TLR3、7、8 和 9、NLRs、ALRs 和 cGLRs 则在细胞器中表达 PRRs。我们知道它们的下游信号通路控制着免疫调节和促炎免疫反应。摘要:免疫细胞代谢或免疫代谢决定着免疫细胞的促炎表型和功能。本文讨论了不同 PRRs(如 TLRs、NLRs、cGLRs 和 RLRs)激活时的免疫代谢重编程(IR)。激活 PRR 的持续时间和类型、研究的物种以及免疫细胞在特定器官的位置是决定 IR 诱导的免疫反应的关键因素:本文介绍了TLR、NLR、cGLR和RLR激活后的IR。了解激活不同 PRRs 时的 IR 对于设计更好的免疫细胞特异性免疫疗法和针对炎症和炎症性疾病的免疫调节剂至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pattern-Recognition Receptors and Immunometabolic Reprogramming: What We Know and What to Explore.

Background: Evolutionarily, immune response is a complex mechanism that protects the host from internal and external threats. Pattern-recognition receptors (PRRs) recognize MAMPs, PAMPs, and DAMPs to initiate a protective pro-inflammatory immune response. PRRs are expressed on the cell membranes by TLR1, 2, 4, and 6 and in the cytosolic organelles by TLR3, 7, 8, and 9, NLRs, ALRs, and cGLRs. We know their downstream signaling pathways controlling immunoregulatory and pro-inflammatory immune response. However, the impact of PRRs on metabolic control of immune cells to control their pro- and anti-inflammatory activity has not been discussed extensively.

Summary: Immune cell metabolism or immunometabolism critically determines immune cells' pro-inflammatory phenotype and function. The current article discusses immunometabolic reprogramming (IR) upon activation of different PRRs, such as TLRs, NLRs, cGLRs, and RLRs. The duration and type of PRR activated, species studied, and location of immune cells to specific organ are critical factors to determine the IR-induced immune response.

Key message: The work herein describes IR upon TLR, NLR, cGLR, and RLR activation. Understanding IR upon activating different PRRs is critical for designing better immune cell-specific immunotherapeutics and immunomodulators targeting inflammation and inflammatory diseases.

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来源期刊
Journal of Innate Immunity
Journal of Innate Immunity 医学-免疫学
CiteScore
10.50
自引率
1.90%
发文量
35
审稿时长
7.5 months
期刊介绍: The ''Journal of Innate Immunity'' is a bimonthly journal covering all aspects within the area of innate immunity, including evolution of the immune system, molecular biology of cells involved in innate immunity, pattern recognition and signals of ‘danger’, microbial corruption, host response and inflammation, mucosal immunity, complement and coagulation, sepsis and septic shock, molecular genomics, and development of immunotherapies. The journal publishes original research articles, short communications, reviews, commentaries and letters to the editors. In addition to regular papers, some issues feature a special section with a thematic focus.
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