解码分支点，揭开剪接的秘密

IF 12.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nature Structural & Molecular Biology Pub Date : 2024-05-13 DOI:10.1038/s41594-024-01308-4

Sara R. Downs, Bec Grace, Jeffrey A. Pleiss

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引用次数: 0

摘要

前 mRNA 剪接需要分支点选择，而分支点选择失调与许多疾病相关。通过两项结构研究，我们可以深入了解活性位点形成的动力学以及可能有助于激活真核生物内含子中正确分支点的剪接体蛋白。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Decoding branch points and unlocking splicing secrets

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Decoding branch points and unlocking splicing secrets

Branch point selection is required for pre-mRNA splicing, and its mis-regulation is associated with many diseases. Two structural studies provide insights into the dynamics of active site formation and the spliceosomal proteins that may contribute to activation of the correct branch point in eukaryotic introns.

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来源期刊

Nature Structural & Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-BIOPHYSICS

CiteScore

22.00

自引率

1.80%

发文量

160

审稿时长

3-8 weeks

期刊介绍： Nature Structural & Molecular Biology is a comprehensive platform that combines structural and molecular research. Our journal focuses on exploring the functional and mechanistic aspects of biological processes, emphasizing how molecular components collaborate to achieve a particular function. While structural data can shed light on these insights, our publication does not require them as a prerequisite.