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NMCR-3、NMCR-4 和 NMCR-5 这三种新型非移动性秋水仙素抗性决定因子的特征：分别对 MCR-3、MCR-7 和 MCR-5 祖细胞的影响

IF 15.8 1区 医学 Q1 PHARMACOLOGY & PHARMACY
Drug Resistance Updates Pub Date : 2024-04-26 DOI:10.1016/j.drup.2024.101088
Yating Guo , Geng Zou , Anusak Kerdsin , Constance Schultsz , Can Hu , Weicheng Bei , Huanchun Chen , Jinquan Li , Yang Zhou
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引用次数: 0

摘要

本研究首次发现了MCR-3、MCR-7和MCR-5的祖先，即NMCR-3、NMCR-4和NMCR-5，并指出气单胞菌是MCR-3和MCR-7的天然储库。此外，还提出了 MCR-3、MCR-7 和 MCR-5 的不同进化模式。
本文章由计算机程序翻译，如有差异，请以英文原文为准。
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Characterization of NMCR-3, NMCR-4 and NMCR-5, three novel non-mobile colistin resistance determinants: Implications for MCR-3, MCR-7, and MCR-5 progenitors, respectively

In this study, the progenitors of MCR-3, MCR-7 and MCR-5, namely NMCR-3, NMCR-4 and NMCR-5, were firstly discovered and indicating Aeromonas was a natural reservoir for MCR-3 and MCR-7. Furthermore, different evolutionary models for MCR-3, MCR-7 and MCR-5 were proposed.

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来源期刊
Drug Resistance Updates
Drug Resistance Updates 医学-药学
CiteScore
26.20
自引率
11.90%
发文量
32
审稿时长
29 days
期刊介绍： Drug Resistance Updates serves as a platform for publishing original research, commentary, and expert reviews on significant advancements in drug resistance related to infectious diseases and cancer. It encompasses diverse disciplines such as molecular biology, biochemistry, cell biology, pharmacology, microbiology, preclinical therapeutics, oncology, and clinical medicine. The journal addresses both basic research and clinical aspects of drug resistance, providing insights into novel drugs and strategies to overcome resistance. Original research articles are welcomed, and review articles are authored by leaders in the field by invitation. Articles are written by leaders in the field, in response to an invitation from the Editors, and are peer-reviewed prior to publication. Articles are clear, readable, and up-to-date, suitable for a multidisciplinary readership and include schematic diagrams and other illustrations conveying the major points of the article. The goal is to highlight recent areas of growth and put them in perspective. *Expert reviews in clinical and basic drug resistance research in oncology and infectious disease *Describes emerging technologies and therapies, particularly those that overcome drug resistance *Emphasises common themes in microbial and cancer research
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