Jennie Clough, Michael Colwill, Andrew Poullis, Richard Pollok, Kamal Patel, Sailish Honap
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引用次数: 0
摘要
炎症性肠病（IBD）包括溃疡性结肠炎（UC）和克罗恩病（CD），是一种在发病率和医疗保健使用方面代价高昂的疾病，目前在西方国家的发病率已接近 1%。IBD 的内镜评估仍是诊断、评估治疗反应和确定术后复发的金标准，但费用昂贵且具有侵入性。生物标志物可促进非侵入性疾病评估，其中 C 反应蛋白和粪便钙蛋白是目前临床实践中最广泛使用的生物标志物。这篇叙述性综述总结了在 UC 和 CD 中使用这两种生物标记物的证据，并在考虑到生物标记物解读局限性的基础上为医疗服务提供者提供了实用指导。我们提出了未来在 IBD 中使用新型生物标记物的证据，并讨论了生物标记物的发现如何实现 IBD 精准医疗的目标。
Biomarkers in inflammatory bowel disease: a practical guide.
Inflammatory bowel disease (IBD), comprising ulcerative colitis (UC) and Crohn's disease (CD), is a costly condition in terms of morbidity and healthcare utilization, with an increasing prevalence now approaching 1% in the Western world. Endoscopic assessment of IBD remains the gold standard for diagnosis, evaluation of treatment response and determination of post-operative recurrence, but is expensive and invasive. Biomarkers can facilitate non-invasive disease assessment, with C-reactive protein and faecal calprotectin as the most widely available biomarkers in current clinical practice. This narrative review summarizes the evidence for their use in both UC and CD and offers practical guidance for healthcare providers taking into account the limitations of biomarker interpretation. We present evidence for the future use of novel biomarkers in IBD and discuss how biomarker discovery could deliver the goal of precision medicine in IBD.
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