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引用次数: 0
摘要
引言研究精浆中中性α-葡萄糖苷酶活性与精液质量的关系。探讨附睾分泌能力对男性生育能力的影响：回顾性分析 2022 年 2 月至 12 月在生殖医学与不孕不育中心接受治疗的 542 名男性，检测精液参数和中性α-葡萄糖苷酶，并对不同组别进行比较。这542名男性包括正常精子症、少精子症、无精子症和畸形精子症：结果：中性α葡萄糖苷酶（NAG）水平在不同精子浓度、活力和形态组间存在统计学差异（P＜0.001）。精浆中的 NAG 活性与射精量和精子浓度呈正相关，而 NAG 水平与精子活力、精子形态分别呈极弱的正相关：我们的研究结果表明，NAG的分泌在一定程度上影响精子的体积、浓度、活力和形态。鉴于 NAG 是附睾中的一种特异性标志酶，而附睾是精子成熟的场所，因此我们可以得出结论，NAG 与精子质量之间存在密切关系。因此，精浆 NAG 在帮助诊断男性不育症方面具有明确的临床价值。
The Effect of Neutral Alpha-Glucosidase on Semen Parameters.
Introduction: The objective of this study was to investigate the relationship between the activity of neutral α-glucosidase in seminal plasma and semen quality and to explore the effect of secretory capability of the epididymis on male fertility.
Methods: A retrospective analysis of 542 men treated in the Center for Reproductive Medicine and Infertility from February to December 2022, the semen parameters and neutral α-glucosidase were tested and compared among different groups. These 542 men included normozoospermia, oligospermia, asthenospermia, and teratozoospermia.
Results: There was statistical difference in neutral alpha-glucosidase (NAG) level among different groups with different sperm concentration, motility, and morphology (p < 0.001). The NAG activity in seminal plasma was positively correlated with ejaculate volume and sperm concentration; meanwhile, a very weak positive correlation was found between NAG level and sperm motility, sperm morphology, respectively.
Conclusions: Our results indicated that the secretion of NAG affected the volume, concentration, motility, and morphology of sperm to a certain extent. Given that NAG is a specific and marker enzyme in epididymis, where is the site of sperm maturation, we can conclude that there is a close relationship between NAG and sperm quality. Therefore, seminal plasma NAG has a definite clinical value in helping diagnosis of male infertility.
期刊介绍：
Concise but fully substantiated international reports of clinically oriented research into science and current management of urogenital disorders form the nucleus of original as well as basic research papers. These are supplemented by up-to-date reviews by international experts on the state-of-the-art of key topics of clinical urological practice. Essential topics receiving regular coverage include the introduction of new techniques and instrumentation as well as the evaluation of new functional tests and diagnostic methods. Special attention is given to advances in surgical techniques and clinical oncology. The regular publication of selected case reports represents the great variation in urological disease and illustrates treatment solutions in singular cases.
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