在体内评估石榴皮提取物对小鼠囊性棘球蚴病的超微结构影响。

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Nashaat E Nassef, Sawsan S Shendi, Abdel-Gawad E Saad, Nancy M Harba, Engy V N Beshay, Asmaa Shams El-Dein Mohamed, Marwa A Gouda
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引用次数: 0

摘要

近十年来,人们对石榴(Punica granatum)果皮的药用和营养价值的兴趣明显增加。本研究考察了单独使用石榴皮提取物(PGE)和与阿苯达唑(ABZ)联合使用对实验室感染小鼠囊性棘球蚴病的超微结构和免疫学变化的影响。结果显示,PGE + ABZ 组的包虫囊肿大小和重量最小(0.48 ± 0.47 毫米,0.17 ± 0.18 克),药效最高(56.2%),组织病理学也有明显改善。透射电子显微镜观察到的超微结构变化包括细胞核碎裂、糖原耗竭和空泡化细胞质中的多个溶酶体,PGE + ABZ 组更常见。接受 ABZ 治疗组的 IFN-γ 水平明显升高,而接受 PGE 治疗组的 IFN-γ 水平明显降低,无论是单独用药还是与 ABZ 联合用药。因此,PGE 提高了 ABZ 的治疗效率,改善了组织病理学和超微结构的变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
An in vivo appraisal of Punica granatum peel extract's ultrastructural effect on cystic echinococcosis in mice.

In the past decade, interest has significantly increased regarding the medicinal and nutritional benefits of pomegranate (Punica granatum) peel. This study examined the effects of using pomegranate peel extract (PGE) alone and in combination with albendazole (ABZ) on ultrastructural and immunological changes in cystic echinococcosis in laboratory-infected mice. Results revealed that the smallest hydatid cyst size and weight (0.48 ± 0.47mm, 0.17 ± 0.18 gm) with the highest drug efficacy (56.2%) was detected in the PGE + ABZ group, which also exhibited marked histopathological improvement. Ultrastructural changes recorded by transmission electron microscopy including fragmentation of the nucleus, glycogen depletion, and multiple lysosomes in vacuolated cytoplasm were more often observed in PGE + ABZ group. IFN-γ levels were significantly increased in the group treated with ABZ, with a notable reduction following PGE treatment, whether administered alone or in combination with ABZ. Thus, PGE enhanced the therapeutic efficiency of ABZ, with improvement in histopathological and ultrastructural changes.

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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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