哈达沙门氏菌与两种不同的传播途径有关,凸显了肠道疾病爆发调查所面临的挑战。

IF 2.5 4区 医学 Q3 INFECTIOUS DISEASES
Joshua M Brandenburg, Gregory Sean Stapleton, Kelly E Kline, Jennifer Khoury, Krystle Mallory, Kimberly D Machesky, Stephen G Ladd-Wilson, Ryan Scholz, Jennifer Freiman, Colin Schwensohn, Alexandra Palacios, Laura Gieraltowski, Zachary Ellison, Beth Tolar, Hattie E Webb, Kaitlin A Tagg, Zainab Salah, Megin Nichols
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引用次数: 0

摘要

2020 年,哈达尔沙门氏菌疫情的爆发与接触非商业性私人(散养)家禽(包括活鸡、火鸡和鸭)有关,导致 848 人患病。从 2020 年底到 2021 年,这种哈达尔沙门氏菌菌株引发的疫情与食用土火鸡有关。核心基因组多焦点序列分型(cgMLST)分析确定,在与散养家禽有关的疫情和与土火鸡有关的疫情中检测到的哈达尔沙门氏菌分离株在基因上密切相关(等位基因数在 0-16 个以内)。流行病学调查和追溯调查无法确定在散养家禽和土火鸡中检测到的哈达沙门氏菌是如何联系在一起的,尽管存在这种遗传相关性。要了解这两起疫情之间的关系,可能需要加强分子特征描述方法,如分析沙门氏菌分离物的庞基因组。同样,在疫情调查期间加强数据收集和进一步研究可能有助于确定这些传播途径是否真的有共同来源,以及家禽业中存在哪些使哈达沙门氏菌持续存在的贮藏库。将流行病学数据收集、更详细的溯源信息和基因组分析工具结合起来的进一步工作对于监测和调查未来的肠道疾病暴发非常重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Salmonella Hadar linked to two distinct transmission vehicles highlights challenges to enteric disease outbreak investigations.

In 2020, an outbreak of Salmonella Hadar illnesses was linked to contact with non-commercial, privately owned (backyard) poultry including live chickens, turkeys, and ducks, resulting in 848 illnesses. From late 2020 to 2021, this Salmonella Hadar strain caused an outbreak that was linked to ground turkey consumption. Core genome multilocus sequence typing (cgMLST) analysis determined that the Salmonella Hadar isolates detected during the outbreak linked to backyard poultry and the outbreak linked to ground turkey were closely related genetically (within 0-16 alleles). Epidemiological and traceback investigations were unable to determine how Salmonella Hadar detected in backyard poultry and ground turkey were linked, despite this genetic relatedness. Enhanced molecular characterization methods, such as analysis of the pangenome of Salmonella isolates, might be necessary to understand the relationship between these two outbreaks. Similarly, enhanced data collection during outbreak investigations and further research could potentially aid in determining whether these transmission vehicles are truly linked by a common source and what reservoirs exist across the poultry industries that allow Salmonella Hadar to persist. Further work combining epidemiological data collection, more detailed traceback information, and genomic analysis tools will be important for monitoring and investigating future enteric disease outbreaks.

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来源期刊
Epidemiology and Infection
Epidemiology and Infection 医学-传染病学
CiteScore
4.10
自引率
2.40%
发文量
366
审稿时长
3-6 weeks
期刊介绍: Epidemiology & Infection publishes original reports and reviews on all aspects of infection in humans and animals. Particular emphasis is given to the epidemiology, prevention and control of infectious diseases. The scope covers the zoonoses, outbreaks, food hygiene, vaccine studies, statistics and the clinical, social and public-health aspects of infectious disease, as well as some tropical infections. It has become the key international periodical in which to find the latest reports on recently discovered infections and new technology. For those concerned with policy and planning for the control of infections, the papers on mathematical modelling of epidemics caused by historical, current and emergent infections are of particular value.
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