可见光促进 2-乙烯基苯并咪唑的自由基级联环化：获得苯并[4,5]咪唑并[1,2-b]异喹啉- 11(6H)-酮。

IF 3.6 2区化学 Q1 CHEMISTRY, ORGANIC

Journal of Organic Chemistry Pub Date : 2024-05-13 DOI:10.1021/acs.joc.4c00444

Yao-Tian Wang, Mai Zhang, Zhi-Xing Liu, Yu-Xin Wu, Qian Yan, Cheng-Liang Liu, Jiang-Sheng Li*, Zhi-Wei Li, Han-Wen Liu and Wen-Sheng Li*,

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引用次数: 0

摘要

本研究开发了一种可见光驱动的 2-乙烯基苯并咪唑衍生物的光氧化自由基级联环化反应。这种化学方法适用于多种 N-芳酰基 2-乙烯基苯并咪唑作为受体，以及卤素化合物（包括烷基卤化物、酰基氯化物和磺酰氯）作为自由基前体。朗格卢瓦试剂也是这一光催化氧化级联过程的有效伙伴。该方案为制备高度官能化的苯并[4,5]咪唑并[1,2-b]异喹啉-11(6H)-酮提供了一种可靠的选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Visible-Light-Promoted Radical Cascade Cyclization of 2-Vinyl Benzimidazoles: Access to Benzo[4,5]imidazo[1,2-b]isoquinolin- 11(6H)-ones

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Visible-Light-Promoted Radical Cascade Cyclization of 2-Vinyl Benzimidazoles: Access to Benzo[4,5]imidazo[1,2-b]isoquinolin- 11(6H)-ones

A visible-light-enabled photoredox radical cascade cyclization of 2-vinyl benzimidazole derivatives is developed. This chemistry is applicable to a wide range of N-aroyl 2-vinyl benzimidazoles as acceptors, and halo compounds, including alkyl halides, acyl chlorides and sulfonyl chlorides, as radical precursors. The Langlois reagent also serves as an effective partner in this photocatalytic oxidative cascade process. This protocol provides a robust alternative for rendering highly functionalized benzo[4,5]imidazo[1,2-b]isoquinolin-11(6H)-ones

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来源期刊

Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.