用于人体 PET 成像的 [11C]CPPC 自动放射合成。

IF 2 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

American journal of nuclear medicine and molecular imaging Pub Date : 2024-04-25 eCollection Date: 2024-01-01 DOI:10.62347/MXKZ6739

Huailei Jiang, Pritam Roy, Yan Guo, Otto Muzik, Eric A Woodcock

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引用次数: 0

摘要

巨噬细胞集落刺激因子 1 受体（CSF1R）几乎只在小胶质细胞中表达，是小胶质细胞可用性成像的生物标记目标。[11C]CPPC与CSF1R具有特异性结合亲和力，其动力学特性适合用于小胶质细胞的体内PET成像。然而，之前的研究报告称放射化学产率较低，这促使我们开展更多研究来优化[11C]CPPC 放射化学。在这项工作中，我们报告了在 Synthra MeIPlus 模块上自动放射性合成[11C]CPPC 的情况，该方法提高了放射化学收率。最终获得的[11C]CPPC 产品具有优异的化学/放射化学纯度和分子活性，有助于高质量的人体 PET 成像应用。

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Automated radiosynthesis of [¹¹C]CPPC for in-human PET imaging applications.

The macrophage colony-stimulating factor 1 receptor (CSF1R) is almost exclusively expressed in microglia, representing a biomarker target for imaging of microglia availability. [¹¹C]CPPC has specific binding affinity to CSF1R and suitable kinetic properties for in vivo PET imaging of microglia. However, previous studies reported a low radiochemical yield, motivating additional research to optimize [¹¹C]CPPC radiochemistry. In this work, we report an automated radiosynthesis of [¹¹C]CPPC on a Synthra MeIPlus module with improved radiochemical yield. The final [¹¹C]CPPC product was obtained with excellent chemical/radiochemical purities and molecular activity, facilitating high-quality in-human PET imaging applications.

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来源期刊

American journal of nuclear medicine and molecular imaging RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

自引率

4.00%

发文量

期刊介绍： The scope of AJNMMI encompasses all areas of molecular imaging, including but not limited to: positron emission tomography (PET), single-photon emission computed tomography (SPECT), molecular magnetic resonance imaging, magnetic resonance spectroscopy, optical bioluminescence, optical fluorescence, targeted ultrasound, photoacoustic imaging, etc. AJNMMI welcomes original and review articles on both clinical investigation and preclinical research. Occasionally, special topic issues, short communications, editorials, and invited perspectives will also be published. Manuscripts, including figures and tables, must be original and not under consideration by another journal.