晚年锻炼可改善大鼠因母体肥胖而导致的衰老轨迹新陈代谢:为时不晚

IF 4.7 3区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Claudia J. Bautista , Luis A. Reyes-Castro , Consuelo Lomas-Soria , Carlos A. Ibáñez , Elena Zambrano
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引用次数: 0

摘要

背景母体肥胖(MO)已被证明会对后代的代谢、氧化、生殖和认知功能产生不利影响。然而,目前还不清楚改变生活方式是否能改善母体肥胖导致的代谢和器官功能障碍,并预防成年后代谢综合征的影响。本研究旨在评估肥胖母亲所生大鼠的后代进行适度的自愿运动是否能改善MO程序对成年中期代谢和肝功能的不利影响。方法对照组(CF1)和MOF1母亲的后代从断奶起就以对照组饮食喂养。成年男性和女性参加每周五天、每次15分钟的运动。对运动干预前后的代谢参数进行分析。结果表明,与 MOF1ex 相比,CF1ex 的男性跑得更多,跑的距离也更长。与此相反,两组中女性的跑步距离相近且保持不变,但比男性跑得更远。在 PND 300 和 450,男性和女性 MOF1 的瘦素、甘油三酯、胰岛素和 HOMA-IR 水平均高于 CF1。然而,男性 MOF1ex 的甘油三酯、胰岛素和 HOMA-IR 水平低于 MOF1。结论:这些研究结果表明,即使在成年中期开始进行适度的自愿运动,也能以性别依赖的方式改善 MO 计划大鼠的代谢结果并延缓代谢老化的加速。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Late-in-life Exercise Ameliorates the Aging Trajectory Metabolism Programmed by Maternal Obesity in Rats: It is Never Too Late

Background

Maternal obesity (MO) has been shown to adversely affect metabolic, oxidative, reproductive, and cognitive function in offspring. However, it is unclear whether lifestyle modification can ameliorate the metabolic and organ dysfunction programmed by MO and prevent the effects of metabolic syndrome in adulthood. This study aimed to evaluate whether moderate voluntary exercise in the offspring of rats born to obese mothers can ameliorate the adverse effects of MO programming on metabolism and liver function in mid-adulthood.

Methods

Offspring of control (CF1) and MOF1 mothers were fed with a control diet from weaning. Adult males and females participated in 15 min exercise sessions five days/week. Metabolic parameters were analyzed before and after the exercise intervention. Liver oxidative stress biomarkers and antioxidant enzymes were analyzed before and after the intervention.

Results

Males showed that CF1ex ran more than MOF1ex and increased the distance covered. In contrast, females in both groups ran similar distances and remained constant but ran more distance than males. At PND 300 and 450, male and female MOF1 had higher leptin, triglycerides, insulin, and HOMA-IR levels than CF1. However, male MOF1ex had lower triglycerides, insulin, and HOMA-IR levels than MOF1. Improvements in liver fat and antioxidant enzymes were observed in CF1ex and MOF1ex males and females compared to their respective CF1 and MOF1 groups.

Conclusion

These findings suggest that moderate voluntary exercise, even when started in mid-adulthood, can improve metabolic outcomes and delay accelerated metabolic aging in MO-programmed rats in a sex-dependent manner.

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来源期刊
Archives of Medical Research
Archives of Medical Research 医学-医学:研究与实验
CiteScore
12.50
自引率
0.00%
发文量
84
审稿时长
28 days
期刊介绍: Archives of Medical Research serves as a platform for publishing original peer-reviewed medical research, aiming to bridge gaps created by medical specialization. The journal covers three main categories - biomedical, clinical, and epidemiological contributions, along with review articles and preliminary communications. With an international scope, it presents the study of diseases from diverse perspectives, offering the medical community original investigations ranging from molecular biology to clinical epidemiology in a single publication.
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