聚卟啉 I 可使顺铂耐药的人类宫颈癌细胞对顺铂治疗敏感。

IF 2 4区 医学 Q3 NUTRITION & DIETETICS
Lu Zhang, Wenzhi Liu, Yu Li, Yuanyuan Fu, Chuanhua Xu, Minmin Yu
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引用次数: 0

摘要

宫颈癌(CC)是一种常见的妇科恶性肿瘤,提高顺铂的敏感性已成为宫颈癌化疗研究的热门话题。多粘菌素 I(Polyphyllin I,PPI)是一种存在于黄连中的强效生物活性化合物,以其抗癌特性而闻名,但它对宫颈癌耐药性的影响仍未得到充分探索。在这项研究中,我们评估了 PPI 对顺铂耐药 CC 细胞的影响,并阐明了其潜在机制。我们的研究结果表明,PPI能增强顺铂耐药CC细胞对药物的敏感性,促进细胞凋亡,抑制细胞迁移。从机理上讲,PPI可调控p53的表达及其靶基因,抑制p53的表达可逆转PPI对耐药CC细胞的增敏作用。总之,PPI有望使顺铂耐药的人类CC细胞对顺铂治疗敏感,这表明它可以作为一种有效的宫颈癌辅助疗法,尤其是对顺铂产生耐药性的病例,从而为进一步临床研究PPI提高现有化疗方案对耐药宫颈癌的疗效提供了良好的基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Polyphyllin I Sensitizes Cisplatin-Resistant Human Cervical Cancer Cells to Cisplatin Treatment.

Cervical cancer (CC) is a common gynecological malignancy, and improving cisplatin sensitivity has become a hot topic in CC chemotherapy research. Polyphyllin I (PPI), a potent bioactive compound found in Rhizoma Paridis, known for its anticancer properties, remains underexplored in CC resistance. In this study, we evaluated PPI's impact on cisplatin-resistant CC cells and elucidated its underlying mechanism. Our findings reveal that PPI enhances the sensitivity of cisplatin-resistant CC cells to the drug, promotes apoptosis, and inhibits cell migration. Mechanistically, PPI was found to regulate p53 expression and its target genes, and suppressing p53 expression reverses PPI's sensitizing effect in drug-resistant CC cells. In conclusion, PPI showed promise in sensitizing cisplatin-resistant human CC cells to cisplatin treatment, suggesting that it could serve as a potent adjunct therapy for cervical cancer, particularly for cases that have developed resistance to cisplatin, thereby providing a promising basis for further clinical investigation into PPI for enhancing the efficacy of existing chemotherapy regimens in resistant cervical cancer.

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来源期刊
CiteScore
5.80
自引率
3.40%
发文量
172
审稿时长
3 months
期刊介绍: This timely publication reports and reviews current findings on the effects of nutrition on the etiology, therapy, and prevention of cancer. Etiological issues include clinical and experimental research in nutrition, carcinogenesis, epidemiology, biochemistry, and molecular biology. Coverage of therapy focuses on research in clinical nutrition and oncology, dietetics, and bioengineering. Prevention approaches include public health recommendations, preventative medicine, behavior modification, education, functional foods, and agricultural and food production policies.
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