Shibo Li , Yanjie Li , Yun Deng , Fei Wang , Da Chen , Bin Lu , Nan Lin
{"title":"肝细胞癌(HCC)患者和非 HCC 患者接触双酚(BPs)的情况:与肝功能生物标志物的关系","authors":"Shibo Li , Yanjie Li , Yun Deng , Fei Wang , Da Chen , Bin Lu , Nan Lin","doi":"10.1016/j.emcon.2024.100351","DOIUrl":null,"url":null,"abstract":"<div><p>Bisphenols (BPs), prevalent endocrine disruptors in daily life, have been widely studied in vitro for their potential to cause liver diseases, including liver cancer. However, there is a dearth of research exploring BP levels in clinical populations with liver issues. This study comprehensively analyzed the distribution and characteristics of ten BPs in paired serum, blood, and urine samples from 197 hepatocellular carcinoma (HCC) patients and 100 non-HCC patients. The study investigated the impact of sociodemographic factors, such as gender, BMI (Body Mass Index), age, drinking, and smoking habits, on BP distribution. Additionally, it analyzed the relationship between BPs and three liver function biomarkers: γ-glutamyl transferase (GGT), alanine aminotransferase (ALT) and alpha-fetoprotein (AFP). Notably, some BP levels were higher in non-HCC patients compared to HCC patients across all three sample types. For HCC patients, the BP concentrations followed the order of serum (29.12 ng/mL) > blood (18.36 ng/mL) > urine (14.91 ng/mL), whereas for non-HCC patients, the order was urine (30.79 ng/mL) > serum (29.51 ng/mL) > blood (24.34 ng/mL). Moreover, BP levels in all patient samples, regardless of HCC status, increased with age. Among HCC patients, females were found to have a higher exposure to BPs compared to males, while the opposite trend was observed in non-HCC patients. Furthermore, the study revealed positive correlations between BPs and liver function indicators, such as ALT and BPAF, BPAP, BPBP; GGT and BPF; and AFP and BPF. These findings suggest a potential association between BPs and liver disease. This comprehensive analysis of BP concentrations in bio-samples from liver disease patients provides valuable insights into the relationship between BPs and liver disease in clinical settings, serving as a reference for future research and clinical practice.</p></div>","PeriodicalId":11539,"journal":{"name":"Emerging Contaminants","volume":null,"pages":null},"PeriodicalIF":5.3000,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2405665024000520/pdfft?md5=4b29d0b8021c0f516af175c4bd7eca2f&pid=1-s2.0-S2405665024000520-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Exposure of Bisphenols (BPs) to hepatocellular carcinoma (HCC) patients and non-HCC patients: Association with liver function biomarkers\",\"authors\":\"Shibo Li , Yanjie Li , Yun Deng , Fei Wang , Da Chen , Bin Lu , Nan Lin\",\"doi\":\"10.1016/j.emcon.2024.100351\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Bisphenols (BPs), prevalent endocrine disruptors in daily life, have been widely studied in vitro for their potential to cause liver diseases, including liver cancer. However, there is a dearth of research exploring BP levels in clinical populations with liver issues. This study comprehensively analyzed the distribution and characteristics of ten BPs in paired serum, blood, and urine samples from 197 hepatocellular carcinoma (HCC) patients and 100 non-HCC patients. The study investigated the impact of sociodemographic factors, such as gender, BMI (Body Mass Index), age, drinking, and smoking habits, on BP distribution. Additionally, it analyzed the relationship between BPs and three liver function biomarkers: γ-glutamyl transferase (GGT), alanine aminotransferase (ALT) and alpha-fetoprotein (AFP). Notably, some BP levels were higher in non-HCC patients compared to HCC patients across all three sample types. For HCC patients, the BP concentrations followed the order of serum (29.12 ng/mL) > blood (18.36 ng/mL) > urine (14.91 ng/mL), whereas for non-HCC patients, the order was urine (30.79 ng/mL) > serum (29.51 ng/mL) > blood (24.34 ng/mL). Moreover, BP levels in all patient samples, regardless of HCC status, increased with age. Among HCC patients, females were found to have a higher exposure to BPs compared to males, while the opposite trend was observed in non-HCC patients. Furthermore, the study revealed positive correlations between BPs and liver function indicators, such as ALT and BPAF, BPAP, BPBP; GGT and BPF; and AFP and BPF. These findings suggest a potential association between BPs and liver disease. This comprehensive analysis of BP concentrations in bio-samples from liver disease patients provides valuable insights into the relationship between BPs and liver disease in clinical settings, serving as a reference for future research and clinical practice.</p></div>\",\"PeriodicalId\":11539,\"journal\":{\"name\":\"Emerging Contaminants\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":5.3000,\"publicationDate\":\"2024-04-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2405665024000520/pdfft?md5=4b29d0b8021c0f516af175c4bd7eca2f&pid=1-s2.0-S2405665024000520-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Emerging Contaminants\",\"FirstCategoryId\":\"1087\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2405665024000520\",\"RegionNum\":2,\"RegionCategory\":\"环境科学与生态学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENVIRONMENTAL SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Emerging Contaminants","FirstCategoryId":"1087","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2405665024000520","RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}
Exposure of Bisphenols (BPs) to hepatocellular carcinoma (HCC) patients and non-HCC patients: Association with liver function biomarkers
Bisphenols (BPs), prevalent endocrine disruptors in daily life, have been widely studied in vitro for their potential to cause liver diseases, including liver cancer. However, there is a dearth of research exploring BP levels in clinical populations with liver issues. This study comprehensively analyzed the distribution and characteristics of ten BPs in paired serum, blood, and urine samples from 197 hepatocellular carcinoma (HCC) patients and 100 non-HCC patients. The study investigated the impact of sociodemographic factors, such as gender, BMI (Body Mass Index), age, drinking, and smoking habits, on BP distribution. Additionally, it analyzed the relationship between BPs and three liver function biomarkers: γ-glutamyl transferase (GGT), alanine aminotransferase (ALT) and alpha-fetoprotein (AFP). Notably, some BP levels were higher in non-HCC patients compared to HCC patients across all three sample types. For HCC patients, the BP concentrations followed the order of serum (29.12 ng/mL) > blood (18.36 ng/mL) > urine (14.91 ng/mL), whereas for non-HCC patients, the order was urine (30.79 ng/mL) > serum (29.51 ng/mL) > blood (24.34 ng/mL). Moreover, BP levels in all patient samples, regardless of HCC status, increased with age. Among HCC patients, females were found to have a higher exposure to BPs compared to males, while the opposite trend was observed in non-HCC patients. Furthermore, the study revealed positive correlations between BPs and liver function indicators, such as ALT and BPAF, BPAP, BPBP; GGT and BPF; and AFP and BPF. These findings suggest a potential association between BPs and liver disease. This comprehensive analysis of BP concentrations in bio-samples from liver disease patients provides valuable insights into the relationship between BPs and liver disease in clinical settings, serving as a reference for future research and clinical practice.
期刊介绍:
Emerging Contaminants is an outlet for world-leading research addressing problems associated with environmental contamination caused by emerging contaminants and their solutions. Emerging contaminants are defined as chemicals that are not currently (or have been only recently) regulated and about which there exist concerns regarding their impact on human or ecological health. Examples of emerging contaminants include disinfection by-products, pharmaceutical and personal care products, persistent organic chemicals, and mercury etc. as well as their degradation products. We encourage papers addressing science that facilitates greater understanding of the nature, extent, and impacts of the presence of emerging contaminants in the environment; technology that exploits original principles to reduce and control their environmental presence; as well as the development, implementation and efficacy of national and international policies to protect human health and the environment from emerging contaminants.