三维生物打印中的聚合物纳米材料在组织工程和药物输送中的应用

Q1 Computer Science

Bioprinting Pub Date : 2024-05-08 DOI:10.1016/j.bprint.2024.e00345

Sarang Han , John P. Fisher , Antonios G. Mikos , Katie J. Hogan

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引用次数: 0

摘要

纳米粒子在三维生物打印（3DBP）中的应用已得到广泛研究，其用途包括药物输送、增强机械性能、生物相容性和生物活性。虽然聚合物纳米粒子在功能化和药物输送方面已得到广泛研究，但目前的综述缺乏对其在三维生物打印中应用的研究，而聚合物纳米粒子还能为三维生物打印的组成和应用增添独特的性能。天然和合成聚合物纳米粒子都已被应用于 3DBP 中，天然聚合物在生物相容性和生物活性方面具有很强的优势，而合成聚合物则能更好地控制纳米材料的特性。在三维打印结构中，聚合物纳米粒子之间的胶体网络可以增强流变性和机械性能以及可打印性。此外，这些纳米材料还可引入刺激响应元素，并输送关键的生物分子，包括生长因子或药物。本文讨论了聚合物纳米粒子目前的应用情况，并重点介绍了它们在三维生物打印技术（3DBP）中用于组织工程和药物输送的潜力。

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Polymeric nanomaterials in 3D bioprinting for tissue engineering and drug delivery applications

Nanoparticles have been broadly investigated in 3D bioprinting (3DBP) for various purposes, including drug delivery, enhanced mechanical performance, biocompatibility, and bioactivity.

While polymeric nanoparticles have been widely studied for functionalization and drug delivery purposes, current reviews lack investigation of their application for 3DBP, where polymeric nanoparticles can also add unique properties in composition and application for 3DBP.

Both natural and synthetic polymeric nanoparticles have been employed in 3DBP, with natural polymers providing a strong advantage for biocompatibility and bioactivity and synthetic polymers enabling more control over nanomaterial properties. In 3D printed structures, the colloidal network between polymeric nanoparticles can enhance rheological and mechanical properties and printability. Additionally, these nanomaterials may introduce stimuli responsive elements and deliver key biomolecules, including growth factors or medications. This paper discusses the current application of polymeric nanoparticles and highlights their potential in 3DBP for tissue engineering and drug delivery specifically.

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来源期刊

Bioprinting Computer Science-Computer Science Applications

CiteScore

11.50

自引率

0.00%

发文量

审稿时长

68 days

期刊介绍： Bioprinting is a broad-spectrum, multidisciplinary journal that covers all aspects of 3D fabrication technology involving biological tissues, organs and cells for medical and biotechnology applications. Topics covered include nanomaterials, biomaterials, scaffolds, 3D printing technology, imaging and CAD/CAM software and hardware, post-printing bioreactor maturation, cell and biological factor patterning, biofabrication, tissue engineering and other applications of 3D bioprinting technology. Bioprinting publishes research reports describing novel results with high clinical significance in all areas of 3D bioprinting research. Bioprinting issues contain a wide variety of review and analysis articles covering topics relevant to 3D bioprinting ranging from basic biological, material and technical advances to pre-clinical and clinical applications of 3D bioprinting.