载药聚乳酸-b-PEO-b-PLA 聚合物胶束的形态和结构研究:耗散粒子动力学模拟研究。

IF 3.2 4区 医学 Q2 ENGINEERING, BIOMEDICAL
Dongmei Liu, Ye Lin, Danping Wang, Yongchao Jin, Kai Gong
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引用次数: 0

摘要

利用耗散粒子动力学(DPD)模拟研究了负载紫杉醇的聚乳酸-b-PEO-b-PLA聚合物胶束的形态和结构。我们重点研究了聚乳酸嵌段长度、聚乳酸-b-PEO-b-PLA 共聚物浓度、紫杉醇药物含量对胶束形态和结构的影响。模拟结果表明(i) 随着聚乳酸嵌段长度的增加,PLA-b-PEO-b-PLA 共聚物与紫杉醇的自组装结构在洋葱状结构(核-中间层-壳)和球形核-壳结构之间变化。PEO 外壳变薄,PLA 核心的尺寸增大。洋葱状结构由 PEO 亲水核、PLA 疏水中间层和 PEO 亲水壳组成,紫杉醇药物主要分布在疏水中间层;(ii) 当加入少量药物时,体系形成球形核壳结构,在一定范围内,球形结构的尺寸随着药物量的增加而增大。当药物含量(体积分数)cdrug = 10%时,可以观察到 PLA4-b-PEO19-b-PLA4 球形结构连接形成杆状结构。当聚乳酸块的长度 NPLA = 8 时,紫杉醇药物浓度 cdrug = 4%,PEO 已不足以完全包裹聚乳酸和紫杉醇药物珠。为了提高药物负载能力,同时保持体系在水溶液中的稳定性,负载紫杉醇的最佳组成为 PLA4-b-PEO19-b-PLA4,药物含量不高于 4%;(iii) 随着 PLA4-b-PEO19-b-PLA4 共聚物浓度从 ccp = 10% 增加到 40%,负载紫杉醇的 PLA4-b-PEO19-b-PLA4 胶束会从洋葱状(核-中间层-壳)过渡到球状(核-壳),再过渡到棒状和片状结构。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Investigation of morphology and structure of drug-loaded PLA-b-PEO-b-PLA polymeric micelle: A dissipative particle dynamics simulations study

The dissipative particle dynamics (DPD) simulation was used to study the morphologies and structures of the paclitaxel-loaded PLA-b-PEO-b-PLA polymeric micelle. We focused on the influences of PLA block length, PLA-b-PEO-b-PLA copolymer concentration, paclitaxel drug content on morphologies and structures of the micelle. Our simulations show that: (i) with the PLA block length increase, the self-assemble structure of PLA-b-PEO-b-PLA copolymers with paclitaxel vary between onion-like structure (core-middle layer-shell) to spherical core-shell structure. The PEO shell thins and the size of the PLA core increases. The onionlike structures are comprised of the PEO hydrophilic core, the PLA hydrophobic middle layer, and the PEO hydrophilic shell, the distribution of the paclitaxel drug predominantly occurs within the hydrophobic intermediate layer; (ii) The system forms a spherical core-shell structure when a small amount of the drug is added, and within a certain range, the size of the spherical structure increases as the drug amount increases. When the drug contents (volume fraction) cdrug = 10%, it can be observed that the PLA4-b-PEO19-b-PLA4 spherical structures connect to form rod-shaped structures. With the length of PLA block NPLA = 8, as the paclitaxel drug concentrations cdrug = 4%, PEO has been insufficient to completely encapsulate the PLA and paclitaxel drug beads. To enhance drug loading capacity while maintaining stability of the system in aqueous solution, the optimal composition for loading paclitaxel is PLA4-b-PEO19-b-PLA4; the drug content is not higher than 4%; (iii) The paclitaxel-loaded PLA4-b-PEO19-b-PLA4 micelle undergo the transition from onionlike (core-middle layer-shell) to spherical (core-shell) to rod-shaped and lamellar structure as the PLA4-b-PEO19-b-PLA4 copolymer concentration increases from ccp = 10% to 40%.

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来源期刊
CiteScore
7.50
自引率
2.90%
发文量
199
审稿时长
12 months
期刊介绍: Journal of Biomedical Materials Research – Part B: Applied Biomaterials is a highly interdisciplinary peer-reviewed journal serving the needs of biomaterials professionals who design, develop, produce and apply biomaterials and medical devices. It has the common focus of biomaterials applied to the human body and covers all disciplines where medical devices are used. Papers are published on biomaterials related to medical device development and manufacture, degradation in the body, nano- and biomimetic- biomaterials interactions, mechanics of biomaterials, implant retrieval and analysis, tissue-biomaterial surface interactions, wound healing, infection, drug delivery, standards and regulation of devices, animal and pre-clinical studies of biomaterials and medical devices, and tissue-biopolymer-material combination products. Manuscripts are published in one of six formats: • original research reports • short research and development reports • scientific reviews • current concepts articles • special reports • editorials Journal of Biomedical Materials Research – Part B: Applied Biomaterials is an official journal of the Society for Biomaterials, Japanese Society for Biomaterials, the Australasian Society for Biomaterials, and the Korean Society for Biomaterials. Manuscripts from all countries are invited but must be in English. Authors are not required to be members of the affiliated Societies, but members of these societies are encouraged to submit their work to the journal for consideration.
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