"肌腱和韧带机械感应和可塑性的分子机制"。

IF 2.1 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of biochemistry Pub Date : 2024-09-30 DOI:10.1093/jb/mvae039

Takahide Matsushima, Asahara Hiroshi

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引用次数: 0

摘要

肌腱和韧带是肌肉骨骼系统的重要组成部分，连接着肌肉和骨骼。在运动领域，肌腱和韧带是脆弱的组织，跟腱断裂和前十字韧带撕裂等损伤会直接影响运动员的职业生涯。此外，重复性创伤和组织退化会导致继发性骨关节炎等疾病，最终影响整体生活质量。最新研究强调了机械应力在维持肌腱和韧带内部平衡中的关键作用。本综述深入探讨了肌腱和韧带的结构以及肌腱组织对机械负荷的可塑性的最新见解。

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Molecular mechanisms of mechanosensing and plasticity of tendons and ligaments.

Tendons and ligaments, crucial components of the musculoskeletal system, connect muscles to bones. In the realm of sports, tendons and ligaments are vulnerable tissues, with injuries such as Achilles tendon rupture and anterior cruciate ligament tears directly impacting an athlete's career. Furthermore, repetitive trauma and tissue degeneration can lead to conditions like secondary osteoarthritis, ultimately affecting the overall quality of life. Recent research highlights the pivotal role of mechanical stress in maintaining homeostasis within tendons and ligaments. This review delves into the latest insights on the structure of tendons and ligaments and the plasticity of tendon tissue in response to mechanical loads.

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来源期刊

Journal of biochemistry 生物-生化与分子生物学

CiteScore

4.80

自引率

3.70%

发文量

101

审稿时长

4-8 weeks

期刊介绍： The Journal of Biochemistry founded in 1922 publishes the results of original research in the fields of Biochemistry, Molecular Biology, Cell, and Biotechnology written in English in the form of Regular Papers or Rapid Communications. A Rapid Communication is not a preliminary note, but it is, though brief, a complete and final publication. The materials described in Rapid Communications should not be included in a later paper. The Journal also publishes short reviews (JB Review) and papers solicited by the Editorial Board.