血小板脂质组学和新脂肪生成:对健康和疾病的影响。

IF 3.1 3区 医学 Q2 HEMATOLOGY
Current Opinion in Hematology Pub Date : 2024-09-01 Epub Date: 2024-05-07 DOI:10.1097/MOH.0000000000000820
Laurence Pirotton, Emma de Cartier d'Yves, Luc Bertrand, Christophe Beauloye, Sandrine Horman
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引用次数: 0

摘要

综述的目的:脂质在血小板结构、信号传导和新陈代谢中起着至关重要的作用。除了捕获外源性脂质,血小板还具有在乙酰-CoA 羧化酶 1(ACC1)调节下从头生成脂质的能力。本综述旨在阐述血小板从头脂质生成和脂质体在血小板生成、功能和疾病中的关键作用:血小板激活后,大约 20% 的血小板脂质体发生重大改变,主要影响含花生四烯酸的种类。多项研究强调了以 ACC1 为关键角色的新脂肪生成对血小板功能的影响。小鼠模型表明,AMPK-ACC1 轴在调节血小板膜花生四烯酸含量、TXA2 分泌和血栓形成方面具有重要作用。在人体血小板中,抑制 ACC1 可降低血小板的反应性。血小板脂质体的重塑以及新的脂质生成对血小板的生物生成也至关重要。在包括心血管疾病和炎症性疾病在内的各种病理情况下,都能观察到血小板脂质体的紊乱,这些改变与血小板反应性的变化之间的联系得到了强调。它与涉及血小板的各种病理情况有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Platelet lipidomics and de novo lipogenesis: impact on health and disease.

Purpose of review: Lipids play vital roles in platelet structure, signaling, and metabolism. In addition to capturing exogenous lipids, platelets possess the capacity for de novo lipogenesis, regulated by acetyl-coA carboxylase 1 (ACC1). This review aims to cover the critical roles of platelet de novo lipogenesis and lipidome in platelet production, function, and diseases.

Recent findings: Upon platelet activation, approximately 20% of the platelet lipidome undergoes significant modifications, primarily affecting arachidonic acid-containing species. Multiple studies emphasize the impact of de novo lipogenesis, with ACC1 as key player, on platelet functions. Mouse models suggest the importance of the AMPK-ACC1 axis in regulating platelet membrane arachidonic acid content, associated with TXA 2 secretion, and thrombus formation. In human platelets, ACC1 inhibition leads to reduced platelet reactivity. Remodeling of the platelet lipidome, alongside with de novo lipogenesis, is also crucial for platelet biogenesis. Disruptions in the platelet lipidome are observed in various pathological conditions, including cardiovascular and inflammatory diseases, with associations between these alterations and shifts in platelet reactivity highlighted.

Summary: The platelet lipidome, partially regulated by ACC-driven de novo lipogenesis, is indispensable for platelet production and function. It is implicated in various pathological conditions involving platelets.

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来源期刊
CiteScore
6.60
自引率
3.10%
发文量
78
审稿时长
6-12 weeks
期刊介绍: ​​​​​​​​Current Opinion in Hematology is an easy-to-digest bimonthly journal covering the most interesting and important advances in the field of hematology. Its hand-picked selection of editors ensure the highest quality selection of unbiased review articles on themes from nine key subject areas, including myeloid biology, Vascular biology, hematopoiesis and erythroid system and its diseases.
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