正链 RNA 病毒基因组复制细胞器:结构、组装和控制。

IF 13.6 2区 生物学 Q1 GENETICS & HEREDITY
Trends in Genetics Pub Date : 2024-08-01 Epub Date: 2024-05-08 DOI:10.1016/j.tig.2024.04.003
Johan A den Boon, Masaki Nishikiori, Hong Zhan, Paul Ahlquist
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引用次数: 0

摘要

正链 RNA [(+)RNA] 病毒包括大流行病 SARS-CoV-2、诱发肿瘤的丙型肝炎病毒、使人衰弱的基孔肯雅病毒 (CHIKV)、致命的脑炎病毒以及许多其他主要病原体。(+)RNA病毒在病毒诱导的复制细胞器(ROs)中复制其RNA基因组,这些细胞器还通过重组和变异演化出新的病毒种类和变种,是重要的病毒控制目标。最近的低温电子显微镜(cryo-EM)发现,病毒 RNA 复制蛋白在 RO 囊泡与细胞质的连接处形成了引人注目的环状 "冠"。这些 "冠 "指导 RO 囊泡的形成、病毒 (-)RNA 和 (+)RNA 的合成和封盖、先天性免疫逃逸,以及将后代 (+)RNA 基因组转入翻译和封装。正在进行的研究揭示了病毒冠的组装、顺序功能、宿主因子相互作用等,对病毒的控制和有益利用具有重要意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Positive-strand RNA virus genome replication organelles: structure, assembly, control.

Positive-strand RNA [(+)RNA] viruses include pandemic SARS-CoV-2, tumor-inducing hepatitis C virus, debilitating chikungunya virus (CHIKV), lethal encephalitis viruses, and many other major pathogens. (+)RNA viruses replicate their RNA genomes in virus-induced replication organelles (ROs) that also evolve new viral species and variants by recombination and mutation and are crucial virus control targets. Recent cryo-electron microscopy (cryo-EM) reveals that viral RNA replication proteins form striking ringed 'crowns' at RO vesicle junctions with the cytosol. These crowns direct RO vesicle formation, viral (-)RNA and (+)RNA synthesis and capping, innate immune escape, and transfer of progeny (+)RNA genomes into translation and encapsidation. Ongoing studies are illuminating crown assembly, sequential functions, host factor interactions, etc., with significant implications for control and beneficial uses of viruses.

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来源期刊
Trends in Genetics
Trends in Genetics 生物-遗传学
CiteScore
20.90
自引率
0.90%
发文量
160
审稿时长
6-12 weeks
期刊介绍: Launched in 1985, Trends in Genetics swiftly established itself as a "must-read" for geneticists, offering concise, accessible articles covering a spectrum of topics from developmental biology to evolution. This reputation endures, making TiG a cherished resource in the genetic research community. While evolving with the field, the journal now embraces new areas like genomics, epigenetics, and computational genetics, alongside its continued coverage of traditional subjects such as transcriptional regulation, population genetics, and chromosome biology. Despite expanding its scope, the core objective of TiG remains steadfast: to furnish researchers and students with high-quality, innovative reviews, commentaries, and discussions, fostering an appreciation for advances in genetic research. Each issue of TiG presents lively and up-to-date Reviews and Opinions, alongside shorter articles like Science & Society and Spotlight pieces. Invited from leading researchers, Reviews objectively chronicle recent developments, Opinions provide a forum for debate and hypothesis, and shorter articles explore the intersection of genetics with science and policy, as well as emerging ideas in the field. All articles undergo rigorous peer-review.
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