新型止痒剂高分子量透明质酸(HMWH)与原胺(一种透皮传输促进剂)的局部联合应用。

IF 2.8 3区 医学 Q2 NEUROSCIENCES
Paul G Green, Jon D Levine
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引用次数: 0

摘要

瘙痒症(瘙痒感)是由多种外源性和内源性物质引起的,这些物质会使特化的感觉神经元(瘙痒感受器和瘙痒神经感受器)变得敏感。遗憾的是,许多急性和慢性瘙痒症患者在接受现有治疗方法时,只能得到部分缓解。我们最近证明,局部应用高分子量透明质酸(HMWH),并结合含有透皮转运促进剂的载体,可有效、持久地逆转与炎症和神经病理性疼痛相关的痛觉感受器敏化。在本实验中,我们测试了 HMWH 外用制剂与原胺(一种透皮转运促进剂)也能减轻瘙痒症的假设。我们报告说,这种 HMWH 外用制剂能明显减轻血清素(5-羟色胺,5-HT)诱发的雄性和雌性大鼠颈后部的搔抓行为。我们的研究结果支持了一种假设,即透皮运输增强剂载体中的局部 HMWH 具有很强的抗瘙痒作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A novel anti-pruritic: Topical co-administration of high molecular weight hyaluronan (HMWH) with protamine, a transdermal transport enhancer.

Pruritis, the sensation of itch, is produced by multiple substances, exogenous and endogenous, that sensitizes specialized sensory neurons (pruriceptors and pruri-nociceptors). Unfortunately, many patients with acute and chronic pruritis obtain only partial relief when treated with currently available treatment modalities. We recently demonstrated that the topical application of high molecular weight hyaluronan (HMWH), when combined with vehicles containing transdermal transport enhancers, produce potent long-lasting reversal of nociceptor sensitization associated with inflammatory and neuropathic pain. In the present experiments we tested the hypothesis that the topical formulation of HMWH with protamine, a transdermal transport enhancer, can also attenuate pruritis. We report that this topical formulation of HMWH markedly attenuates scratching behavior at the nape of the neck induced by serotonin (5-hydroxytryptamine, 5-HT), in male and female rats. Our results support the hypothesis that topical HMWH in a transdermal transport enhancer vehicle is a strong anti-pruritic.

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来源期刊
Molecular Pain
Molecular Pain 医学-神经科学
CiteScore
5.60
自引率
3.00%
发文量
56
审稿时长
6-12 weeks
期刊介绍: Molecular Pain is a peer-reviewed, open access journal that considers manuscripts in pain research at the cellular, subcellular and molecular levels. Molecular Pain provides a forum for molecular pain scientists to communicate their research findings in a targeted manner to others in this important and growing field.
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