通过分离囚禁相关的繁殖激素变化对绒猴长期压力的初步研究

IF 0.8 4区农林科学 Q3 VETERINARY SCIENCES

Journal of Medical Primatology Pub Date : 2024-05-09 DOI:10.1111/jmp.12701

Ji Woon Kim, Yoon Beom Lee, Woori Jo, Tae-Ku Kang, Na-Hye Park, Gwang-Hoon Lee

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引用次数: 0

摘要

背景：压力会严重影响雌猴的身心健康，并将其生理影响延伸到雌猴的月经周期，阻碍下丘脑-垂体-性腺轴（HPG），并通过抑制性刺激激素影响生育能力：在这项研究中，我们仔细分析了三只雌性眼镜猴的月经周期和相应的激素波动：初步结果显示，皮质醇、卵泡刺激素（FSH）和雌二醇的水平低于正常水平。一只猴子出现了无排卵性出血，这可能与压力有关。与皮质醇相反，与皮质醇水平相关的碱性磷酸酶（ALP）在月经期猴子中持续升高，这表明它有可能成为压力指标。非月经组的体重减轻与压力有关，这与观察到的ALP趋势一致：结论：非月经期猴子可能比月经期猴子经历更多压力。这项研究的意义超出了灵长类动物研究的范围，为提高雌性眼镜猴的福利提供了一种有价值的方法。

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Preliminary investigation into long-term stress by isolated captivity-related changes of reproduction hormones in Cynomolgus monkey

Background

Stress profoundly affects physical and emotional well-being, extending its physiological influence to the female menstrual cycle, impeding the hypothalamus–pituitary–gonadal (HPG) axis, and affecting fertility by suppressing sex-stimulating hormones.

Methods

In this study, we meticulously analyzed menstrual cycles and corresponding hormonal fluctuations in three female Cynomolgus monkeys.

Results

The preliminary findings indicated lower-than-normal levels of cortisol, follicle-stimulating hormone (FSH), and estradiol. Anovulatory bleeding occurred in one monkey, which could be linked to stress. In contrast to cortisol, alkaline phosphatase (ALP), which is correlated to cortisol levels, was consistently elevated in menstruating monkeys, suggesting its potential as a stress indicator. The non-menstruating group exhibited stress-related weight loss, emphasizing the observed ALP trends.

Conclusions

Non-menstruating monkeys may experience more stress than menstruating monkeys. The implications of this study extend beyond the confines of primate studies and offer a valuable method for enhancing the welfare of female Cynomolgus monkeys.

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来源期刊

Journal of Medical Primatology 生物-动物学

CiteScore

1.40

自引率

42.90%

发文量

审稿时长

6 months

期刊介绍： The Journal of Medical Primatology publishes research on non-human primates as models to study, prevent, and/or treat human diseases; subjects include veterinary medicine; morphology, physiology, reproductive biology, central nervous system, and cardiovascular diseases; husbandry, handling, experimental methodology, and management of non-human primate colonies and laboratories; non-human primate wildlife management; and behaviour and sociology as related to medical conditions and captive non-human primate needs. Published material includes: Original Manuscripts - research results; Case Reports - scientific documentation of a single clinical study; Short Papers - case histories, methodologies, and techniques of particular interest; Letters to the Editor - opinions, controversies and sporadic scientific observations; Perspectives – opinion piece about existing research on a particular topic; Minireviews – a concise review of existing literature; Book Reviews by invitation; Special Issues containing selected papers from specialized meetings; and Editorials and memoriams authored by the Editor-in-Chief.