含有孜然和多花蝙蝠葛精油的藻酸盐纳米粒子具有良好的抗癌和抗菌效果

IF 3 Q3 MATERIALS SCIENCE, BIOMATERIALS
International Journal of Biomaterials Pub Date : 2024-05-02 eCollection Date: 2024-01-01 DOI:10.1155/2024/5556838
Mahmoud Osanloo, Razieh Ranjbar, Elham Zarenezhad
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引用次数: 0

摘要

癌症和细菌感染是全球关注的主要健康问题,推动了对创新药物的需求。本研究探讨了藻酸盐纳米颗粒作为潜在的药物输送系统,其中装载了孜然和多花蓼的精油(EO)。研究采用气相色谱-质谱(GC-MS)、动态光散射(DLS)、zetasizer、衰减全反射-傅立叶变换红外光谱(ATR-FTIR)和紫外-可见光谱(UV-Vis)等技术对纳米颗粒进行了全面表征。此外,还评估了它们对两种人类皮肤癌细胞系(A-375 和 A-431)和三种细菌(大肠杆菌、铜绿假单胞菌和金黄色葡萄球菌)的生物特性。藻酸盐纳米颗粒含有西米露和多花植物萃取精华,尺寸分别为 160 ± 8 nm 和 151 ± 10 nm。它们的 zeta 电位和封装效率分别为 -18 ± 1 mV 和 79 ± 4%,以及 -27 ± 2 mV 和 86 ± 5%。对测试细胞系和细菌的 IC50 值显示,含有多花梓树环氧乙烷的纳米粒子具有卓越的功效。考虑到所提出的纳米颗粒具有适当的功效,其简单的制备方法和低廉的成本表明其具有进一步进行体内研究的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Alginate Nanoparticles Containing Cuminum cyminum and Zataria multiflora Essential Oils with Promising Anticancer and Antibacterial Effects.

Cancer and bacterial infections are major global health concerns driving the need for innovative medicines. This study investigated alginate nanoparticles loaded with essential oils (EOs) from Cuminum cyminum and Zataria multiflora as potential drug delivery systems. The nanoparticles were comprehensively characterized using techniques such as gas chromatography-mass spectrometry (GC-MS), dynamic light scattering (DLS), zetasizer, attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), and ultraviolet-visible spectroscopy (UV-Vis). Their biological properties against two human skin cancer cell lines (A-375 and A-431) and three bacteria (Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus) were also evaluated. Alginate nanoparticles containing C. cyminum and Z. multiflora EOs exhibited sizes of 160 ± 8 nm and 151 ± 10 nm, respectively. Their zeta potentials and encapsulation efficiencies were -18 ± 1 mV and 79 ± 4%, as well as -27 ± 2 mV and 86 ± 5%, respectively. The IC50 values against the tested cell lines and bacteria revealed superior efficacy for nanoparticles containing Z. multiflora EO. Considering the proper efficacy of the proposed nanoparticles, the straightforward preparation method and low cost suggest their potential for further in vivo studies.

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来源期刊
International Journal of Biomaterials
International Journal of Biomaterials MATERIALS SCIENCE, BIOMATERIALS-
CiteScore
4.30
自引率
3.20%
发文量
50
审稿时长
21 weeks
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