系统性红斑狼疮患者的头痛:LUNA登记横断面研究。

IF 1.9 4区 医学 Q3 RHEUMATOLOGY
Lupus Pub Date : 2024-08-01 Epub Date: 2024-05-09 DOI:10.1177/09612033241254168
Ryota Takamatsu, Yasuhiro Shimojima, Dai Kishida, Takanori Ichikawa, Ken-Ichi Ueno, Yoshia Miyawaki, Nobuyuki Yajima, Ken-Ei Sada, Kunihiro Ichinose, Ryusuke Yoshimi, Shigeru Ohno, Hiroshi Kajiyama, Michio Fujiwara, Shuzo Sato, Takashi Kida, Yusuke Matsuo, Keisuke Nishimura, Toshihide Toriyama, Yoshiki Sekijima
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引用次数: 0

摘要

研究目的本研究利用日本多中心队列的登记资料,调查了系统性红斑狼疮(SLE)患者头痛的临床相关因素:这项横断面研究使用偏头痛残疾评估(MIDAS)问卷分析了有头痛发作的系统性红斑狼疮患者的临床信息。研究评估了头痛患者(HA 患者)和无头痛患者(非 HA 患者)之间的比较结果,以及根据 MIDAS 评分对头痛引起的日常生活残疾等级进行比较的重要结果。为了确定头痛的相关因素,我们进行了多变量逻辑回归分析:我们分析了 369 名患者(中位年龄 45 岁;女性占 90.8%),其中 113 名 HA 患者明显比非 HA 患者年轻(p < .005)。HA患者出现光敏感、皮疹和粘膜溃疡的频率明显高于非HA患者(p < .05)。年龄和光敏感性与头痛明显相关(几率比(OR)为 0.93,95% 置信区间(CI)为 0.95-0.99;OR 为 2.11,95% 置信区间(CI)为 1.29-3.49)。在 HA 患者中,低补体血症与轻度以上残疾显著相关(OR 2.89,95% CI 1.14-7.74),而皮疹在中度和重度残疾患者中显著可见:这项研究表明,光敏感性是系统性红斑狼疮患者头痛的一种相关表现。结论:这项研究表明,光敏感性是系统性红斑狼疮患者头痛的相关表现,持续的低补体血症可导致头痛引起的日常生活残疾,而皮疹可能是中度/重度头痛引起的残疾患者的主要表现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Headache in systemic lupus erythematosus: The LUNA registry cross-sectional study.

Objectives: This study investigated the clinically relevant factors for headaches in patients with systemic lupus erythematosus (SLE) using a registry from a Japanese multicenter cohort.

Methods: This cross-sectional study analysed the clinical information of patients with SLE who experienced headache episodes using the Migraine Disability Assessment (MIDAS) questionnaire. Significant findings in the comparisons between patients with headache (HA patients) and those without headache (non-HA patients) and in the comparisons depending on the grades of headache-induced disability in daily life based on the MIDAS scores were evaluated. Multivariate logistic regression analyses were performed to identify the relevant factors for headache.

Results: We analyzed 369 patients (median age, 45 years; female, 90.8%), including 113 HA patients who were significantly younger than non-HA patients (p < .005). HA patients had significantly higher frequencies of photosensitivity, rashes, and mucosal ulcers than non-HA patients (p < .05). Age and photosensitivity were significantly associated with headache (odds ratio (OR) 0.93, 95% confidence interval (CI) 0.95-0.99; OR 2.11, 95% CI 1.29-3.49, respectively). In the HA patients, hypocomplementemia was significantly associated with a disability of more than mild grade (OR 2.89, 95% CI 1.14-7.74), while rash was significantly observed in those presenting with moderate and severe disability.

Conclusion: This study suggests that photosensitivity is a relevant manifestation of headache in patients with SLE. Persistent hypocomplementemia can contribute to headache-induced disability in daily life, whereas a rash may be a dominant manifestation in patients presenting with moderate/severe headache-induced disability.

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来源期刊
Lupus
Lupus 医学-风湿病学
CiteScore
4.20
自引率
11.50%
发文量
225
审稿时长
1 months
期刊介绍: The only fully peer reviewed international journal devoted exclusively to lupus (and related disease) research. Lupus includes the most promising new clinical and laboratory-based studies from leading specialists in all lupus-related disciplines. Invaluable reading, with extended coverage, lupus-related disciplines include: Rheumatology, Dermatology, Immunology, Obstetrics, Psychiatry and Cardiovascular Research…
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