Jieling Zheng, Guochang Wang, Qian Ru, Yun Yang, Li Su, Wenlong Lv, Chunlin Ke, Peirong Wang, Xiaohui Liu, Li Zhang, Feng Liu, Weibing Miao
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The radiotracer uptake derived from two PETs was also compared.</p><p><strong>Results: </strong>For treatment-naïve patients, [<sup>68</sup>Ga]Ga-DOTATATE PET/CT showed identical sensitivity for the primary tumours but clearer tumor delineation induced by higher tumour-to-background (TBR) ratio (19.1 ± 8.7 vs. 12.4 ± 7.7, P = 0.003), compared with [<sup>68</sup>Ga]Ga-FAPI PET/CT. Regarding cervical lymph node (CLN) metastases, [<sup>68</sup>Ga]Ga-DOTATATE PET had significantly better sensitivity and accuracy based on neck sides (98% vs. 82%, P < 0.001; 99% vs. 88% P = 0.008), neck levels (98% vs. 78%, 99% vs. 97%; both P < 0.001) and individual nodes (89% vs. 56%, 91% vs. 76%; both P < 0.001), and higher TBR (8.1 ± 4.1 vs. 6.3 ± 3.7, P < 0.001). Additionally, [<sup>68</sup>Ga]Ga-DOTATATE PET/CT revealed higher sensitivity and accuracy for distant metastases (96% vs. 53%, 95% vs. 52%; both P < 0.001), particularly in bone metastases (99% vs. 49%, 97% vs. 49%; both P < 0.001). For post-treatment patients, [<sup>68</sup>Ga]Ga-DOTATATE PET/CT identified one more true-negative case than [<sup>68</sup>Ga]Ga-FAPI PET/CT.</p><p><strong>Conclusion: </strong>[<sup>68</sup>Ga]Ga-DOTATATE PET/CT performed better than [<sup>68</sup>Ga]Ga-FAPI PET/CT in visualizing the primary tumours, detecting the metastatic lesions and identifying the local recurrence, suggesting [<sup>68</sup>Ga]Ga-DOTATATE PET/CT may be superior to [<sup>68</sup>Ga]Ga-FAPI PET/CT for NPC staging.</p>","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":null,"pages":null},"PeriodicalIF":8.6000,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A head-to-head comparison of [<sup>68</sup>Ga]Ga-DOTATATE and [<sup>68</sup>Ga]Ga-FAPI PET/CT in patients with nasopharyngeal carcinoma: a single-center, prospective study.\",\"authors\":\"Jieling Zheng, Guochang Wang, Qian Ru, Yun Yang, Li Su, Wenlong Lv, Chunlin Ke, Peirong Wang, Xiaohui Liu, Li Zhang, Feng Liu, Weibing Miao\",\"doi\":\"10.1007/s00259-024-06744-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>We aimed to compare the staging efficiency of [<sup>68</sup>Ga]Ga-DOTATATE and [<sup>68</sup>Ga]Ga-FAPI PET/CT in nasopharyngeal carcinoma (NPC) patients.</p><p><strong>Methods: </strong>Thirty-nine patients with pathologically confirmed NPC were enrolled in this prospective study. Each patient underwent paired [<sup>68</sup>Ga]Ga-DOTATATE and [<sup>68</sup>Ga]Ga-FAPI PET/CT on 2 successive days. The accuracy of two PET/CT for assessing T, N, and M stages was compared by using head-and-neck MRI, histopathologic diagnosis and follow-up results as reference standards. The radiotracer uptake derived from two PETs was also compared.</p><p><strong>Results: </strong>For treatment-naïve patients, [<sup>68</sup>Ga]Ga-DOTATATE PET/CT showed identical sensitivity for the primary tumours but clearer tumor delineation induced by higher tumour-to-background (TBR) ratio (19.1 ± 8.7 vs. 12.4 ± 7.7, P = 0.003), compared with [<sup>68</sup>Ga]Ga-FAPI PET/CT. Regarding cervical lymph node (CLN) metastases, [<sup>68</sup>Ga]Ga-DOTATATE PET had significantly better sensitivity and accuracy based on neck sides (98% vs. 82%, P < 0.001; 99% vs. 88% P = 0.008), neck levels (98% vs. 78%, 99% vs. 97%; both P < 0.001) and individual nodes (89% vs. 56%, 91% vs. 76%; both P < 0.001), and higher TBR (8.1 ± 4.1 vs. 6.3 ± 3.7, P < 0.001). Additionally, [<sup>68</sup>Ga]Ga-DOTATATE PET/CT revealed higher sensitivity and accuracy for distant metastases (96% vs. 53%, 95% vs. 52%; both P < 0.001), particularly in bone metastases (99% vs. 49%, 97% vs. 49%; both P < 0.001). 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引用次数: 0
摘要
目的:我们旨在比较[68Ga]Ga-DOTATATE和[68Ga]Ga-FAPI PET/CT对鼻咽癌患者的分期效率:这项前瞻性研究共纳入39例经病理证实的鼻咽癌患者。每位患者连续两天接受[68Ga]Ga-DOTATATE和[68Ga]Ga-FAPI PET/CT检查。以头颈部核磁共振成像、组织病理学诊断和随访结果为参考标准,比较了两种 PET/CT 评估 T、N 和 M 期的准确性。同时还比较了两种 PET 的放射性示踪剂摄取量:结果:与[68Ga]Ga-FAPI PET/CT相比,[68Ga]Ga-DOTATATE PET/CT对未经治疗的患者显示出相同的原发肿瘤敏感性,但由于肿瘤与背景(TBR)比值更高(19.1 ± 8.7 vs. 12.4 ± 7.7,P = 0.003),因此肿瘤分界更清晰。在颈部淋巴结(CLN)转移方面,[68Ga]Ga-DOTATATE PET的敏感性和准确性明显高于[68Ga]Ga-FAPI PET/CT(98% vs. 82%, P 68Ga]Ga-DOTATATE PET/CT对远处转移的敏感性和准确性更高(96% vs. 53%, 95% vs. 52%; P 68Ga]Ga-DOTATATE PET/CT比[68Ga]Ga-FAPI PET/CT多发现一个真阴性病例):结论:[68Ga]Ga-DOTATATE PET/CT在显示原发肿瘤、检测转移病灶和识别局部复发方面的表现优于[68Ga]Ga-FAPI PET/CT,表明[68Ga]Ga-DOTATATE PET/CT在鼻咽癌分期方面可能优于[68Ga]Ga-FAPI PET/CT。
A head-to-head comparison of [68Ga]Ga-DOTATATE and [68Ga]Ga-FAPI PET/CT in patients with nasopharyngeal carcinoma: a single-center, prospective study.
Purpose: We aimed to compare the staging efficiency of [68Ga]Ga-DOTATATE and [68Ga]Ga-FAPI PET/CT in nasopharyngeal carcinoma (NPC) patients.
Methods: Thirty-nine patients with pathologically confirmed NPC were enrolled in this prospective study. Each patient underwent paired [68Ga]Ga-DOTATATE and [68Ga]Ga-FAPI PET/CT on 2 successive days. The accuracy of two PET/CT for assessing T, N, and M stages was compared by using head-and-neck MRI, histopathologic diagnosis and follow-up results as reference standards. The radiotracer uptake derived from two PETs was also compared.
Results: For treatment-naïve patients, [68Ga]Ga-DOTATATE PET/CT showed identical sensitivity for the primary tumours but clearer tumor delineation induced by higher tumour-to-background (TBR) ratio (19.1 ± 8.7 vs. 12.4 ± 7.7, P = 0.003), compared with [68Ga]Ga-FAPI PET/CT. Regarding cervical lymph node (CLN) metastases, [68Ga]Ga-DOTATATE PET had significantly better sensitivity and accuracy based on neck sides (98% vs. 82%, P < 0.001; 99% vs. 88% P = 0.008), neck levels (98% vs. 78%, 99% vs. 97%; both P < 0.001) and individual nodes (89% vs. 56%, 91% vs. 76%; both P < 0.001), and higher TBR (8.1 ± 4.1 vs. 6.3 ± 3.7, P < 0.001). Additionally, [68Ga]Ga-DOTATATE PET/CT revealed higher sensitivity and accuracy for distant metastases (96% vs. 53%, 95% vs. 52%; both P < 0.001), particularly in bone metastases (99% vs. 49%, 97% vs. 49%; both P < 0.001). For post-treatment patients, [68Ga]Ga-DOTATATE PET/CT identified one more true-negative case than [68Ga]Ga-FAPI PET/CT.
Conclusion: [68Ga]Ga-DOTATATE PET/CT performed better than [68Ga]Ga-FAPI PET/CT in visualizing the primary tumours, detecting the metastatic lesions and identifying the local recurrence, suggesting [68Ga]Ga-DOTATATE PET/CT may be superior to [68Ga]Ga-FAPI PET/CT for NPC staging.
期刊介绍:
The European Journal of Nuclear Medicine and Molecular Imaging serves as a platform for the exchange of clinical and scientific information within nuclear medicine and related professions. It welcomes international submissions from professionals involved in the functional, metabolic, and molecular investigation of diseases. The journal's coverage spans physics, dosimetry, radiation biology, radiochemistry, and pharmacy, providing high-quality peer review by experts in the field. Known for highly cited and downloaded articles, it ensures global visibility for research work and is part of the EJNMMI journal family.