非结核分枝杆菌对卡介苗效力的影响:叙述性综述

IF 1.9 Q3 INFECTIOUS DISEASES
Fatemeh Ghasemi , Jalil Kardan-Yamchi , Mohsen Heidary , Morteza Karami-Zarandi , Sousan Akrami , Abbas Maleki , Saeed Khoshnood , Hossein Kazemian
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引用次数: 0

摘要

结核分枝杆菌细菌病原体是目前全球结核病(TB)流行的罪魁祸首。卡介苗(Bacille Calmette-Guérin,BCG)是目前唯一获批的结核病疫苗,可成功预防新生儿播散性疾病。然而,它对成人肺结核的疗效却不尽相同。疫苗的这种保护作用在不同人群和不同地理区域之间存在很大差异,造成这一问题的原因之一是特定人群接触非结核分枝杆菌(NTM)的机会增多。大量研究表明,接触非结核分枝杆菌会导致宿主免疫系统启动不当。还有人认为,NTM 菌可能是卡介苗对结核杆菌效力降低的罪魁祸首。某些人群接触更多的非结核菌会对卡介苗的效力产生不同的影响。此外,根据非结核菌接触途径和存活率的不同,接触非结核菌会对卡介苗的效力产生相反的影响。详细了解非结核菌暴露对卡介苗药效的影响对于目前开发新型结核病疫苗的工作至关重要,因为这可能最终成为成功的关键因素。本研究的目的是回顾在动物模型中有关非结核菌对卡介苗效力影响的研究结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of non-tuberculous mycobacteria on BCG vaccine efficacy: A narrative review

The Mycobacterium tuberculosis bacterial pathogen is responsible for the ongoing global tuberculosis (TB) epidemic. Bacille Calmette-Guérin (BCG), the only currently approved TB vaccine, is successful in preventing disseminated disease in newborns. However, it has a variable efficacy against pulmonary TB in adults. This protective effect of the vaccine varies greatly among different populations and geographical areas, which the increased exposure of particular populations to non-tuberculous mycobacteria (NTM) is considered as one of the reasons for this issue. Numerous studies have shown that exposure to NTM species causes the host immune system to be improperly primed. It has also been suggested that NTM species may be blamed for reduction in BCG vaccine effectiveness against M. tuberculosis. The increased exposure of certain populations to NTM has diverse effects on BCG efficacy. Moreover, the exposure to NTM can induce opposite effects on BCG efficacy depending on the NTM exposure route and survivability. A detailed understanding of the impact of NTM exposure on the efficacy of the BCG vaccine is essential for ongoing efforts to develop new TB vaccines as it may ultimately be a crucial success factor. The aim of this study was to review the findings of the studies focusing on the effects of NTM on BCG vaccine efficacy in animal models.

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来源期刊
Journal of Clinical Tuberculosis and Other Mycobacterial Diseases
Journal of Clinical Tuberculosis and Other Mycobacterial Diseases Medicine-Pulmonary and Respiratory Medicine
CiteScore
4.00
自引率
5.00%
发文量
44
审稿时长
30 weeks
期刊介绍: Journal of Clinical Tuberculosis and Mycobacterial Diseases aims to provide a forum for clinically relevant articles on all aspects of tuberculosis and other mycobacterial infections, including (but not limited to) epidemiology, clinical investigation, transmission, diagnosis, treatment, drug-resistance and public policy, and encourages the submission of clinical studies, thematic reviews and case reports. Journal of Clinical Tuberculosis and Mycobacterial Diseases is an Open Access publication.
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