Charlotte Dubucs MD , Van N’Go MS , Anthony Caillet Bsc , Erika-Alejandra Cifuentes MS , Anna-Belle Beau PhD , Félix Frémont MD , Caroline Hurault-Delarue PhD , Monique Courtade-Saïdi MD, PhD , Christine Damase-Michel PharmD, PhD
{"title":"EFEMEREYE 研究：EFEMERIS 健康数据库中的产前药物接触与眼部异常发生率。","authors":"Charlotte Dubucs MD , Van N’Go MS , Anthony Caillet Bsc , Erika-Alejandra Cifuentes MS , Anna-Belle Beau PhD , Félix Frémont MD , Caroline Hurault-Delarue PhD , Monique Courtade-Saïdi MD, PhD , Christine Damase-Michel PharmD, PhD","doi":"10.1016/j.jaapos.2024.103931","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose</h3><p>To describe ocular anomalies (OAs) in children and fetuses in a French general population, to estimate their prevalence, and to investigate a possible association between prenatal medication exposure and the occurrence of OA in utero or in early childhood.</p></div><div><h3>Methods</h3><p>We conducted a case-control study using the EFEMERIS cohort, a database containing pregnancies registered in Haute-Garonne and their outcomes. We collected OA descriptions of fetuses at the time of pregnancy termination or of children at birth and the results of eye examinations of children at 9 months and 2 years of age.</p></div><div><h3>Results</h3><p>The prevalence of overall OAs was 2.13%, of which 0.04% were congenital ocular malformations (COMs). A total of 2,968 cases and 136,619 controls were selected for analysis. There was a significant difference between the two groups with regard to prenatal exposure to medications for the digestive tract and metabolism, the cardiovascular system, and the respiratory system. Multivariable analysis revealed an increased risk of OA in children of mothers exposed to magnesium during and 1 month before pregnancy (OR = 1.24; 95% CI, 1.11-1.38).</p></div><div><h3>Conclusions</h3><p>This first pharmaco-epidemiological study on OA in France suggests that OA may be associated with exposure to commonly used medications. Given the rarity of COM, larger, international studies are warranted.</p></div>","PeriodicalId":50261,"journal":{"name":"Journal of Aapos","volume":"28 3","pages":"Article 103931"},"PeriodicalIF":1.2000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The EFEMEREYE Study: prenatal medication exposure and ocular anomaly occurrence in EFEMERIS health database\",\"authors\":\"Charlotte Dubucs MD , Van N’Go MS , Anthony Caillet Bsc , Erika-Alejandra Cifuentes MS , Anna-Belle Beau PhD , Félix Frémont MD , Caroline Hurault-Delarue PhD , Monique Courtade-Saïdi MD, PhD , Christine Damase-Michel PharmD, PhD\",\"doi\":\"10.1016/j.jaapos.2024.103931\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Purpose</h3><p>To describe ocular anomalies (OAs) in children and fetuses in a French general population, to estimate their prevalence, and to investigate a possible association between prenatal medication exposure and the occurrence of OA in utero or in early childhood.</p></div><div><h3>Methods</h3><p>We conducted a case-control study using the EFEMERIS cohort, a database containing pregnancies registered in Haute-Garonne and their outcomes. We collected OA descriptions of fetuses at the time of pregnancy termination or of children at birth and the results of eye examinations of children at 9 months and 2 years of age.</p></div><div><h3>Results</h3><p>The prevalence of overall OAs was 2.13%, of which 0.04% were congenital ocular malformations (COMs). A total of 2,968 cases and 136,619 controls were selected for analysis. There was a significant difference between the two groups with regard to prenatal exposure to medications for the digestive tract and metabolism, the cardiovascular system, and the respiratory system. Multivariable analysis revealed an increased risk of OA in children of mothers exposed to magnesium during and 1 month before pregnancy (OR = 1.24; 95% CI, 1.11-1.38).</p></div><div><h3>Conclusions</h3><p>This first pharmaco-epidemiological study on OA in France suggests that OA may be associated with exposure to commonly used medications. Given the rarity of COM, larger, international studies are warranted.</p></div>\",\"PeriodicalId\":50261,\"journal\":{\"name\":\"Journal of Aapos\",\"volume\":\"28 3\",\"pages\":\"Article 103931\"},\"PeriodicalIF\":1.2000,\"publicationDate\":\"2024-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Aapos\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1091853124002015\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Aapos","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1091853124002015","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
The EFEMEREYE Study: prenatal medication exposure and ocular anomaly occurrence in EFEMERIS health database
Purpose
To describe ocular anomalies (OAs) in children and fetuses in a French general population, to estimate their prevalence, and to investigate a possible association between prenatal medication exposure and the occurrence of OA in utero or in early childhood.
Methods
We conducted a case-control study using the EFEMERIS cohort, a database containing pregnancies registered in Haute-Garonne and their outcomes. We collected OA descriptions of fetuses at the time of pregnancy termination or of children at birth and the results of eye examinations of children at 9 months and 2 years of age.
Results
The prevalence of overall OAs was 2.13%, of which 0.04% were congenital ocular malformations (COMs). A total of 2,968 cases and 136,619 controls were selected for analysis. There was a significant difference between the two groups with regard to prenatal exposure to medications for the digestive tract and metabolism, the cardiovascular system, and the respiratory system. Multivariable analysis revealed an increased risk of OA in children of mothers exposed to magnesium during and 1 month before pregnancy (OR = 1.24; 95% CI, 1.11-1.38).
Conclusions
This first pharmaco-epidemiological study on OA in France suggests that OA may be associated with exposure to commonly used medications. Given the rarity of COM, larger, international studies are warranted.
期刊介绍：
Journal of AAPOS presents expert information on children''s eye diseases and on strabismus as it affects all age groups. Major articles by leading experts in the field cover clinical and investigative studies, treatments, case reports, surgical techniques, descriptions of instrumentation, current concept reviews, and new diagnostic techniques. The Journal is the official publication of the American Association for Pediatric Ophthalmology and Strabismus.
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