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引用次数: 0
摘要
背景：嗜血细胞淋巴组织细胞增多症（HLH嗜血细胞淋巴组织细胞增多症（HLH）是登革热的一种罕见并发症，有可能危及生命，死亡率很高。因此，本研究旨在调查登革热中嗜血细胞淋巴细胞增多症的发病率、管理和预后：方法：检索从开始到 2024 年 1 月 31 日的主要电子数据库，包括 PubMed、ScienceDirect 和 Ovid SP，以确定相关研究。采用随机效应通用逆方差模型计算汇总患病率和死亡率，并得出95%的CI。所有统计分析均使用 R 程序进行：本荟萃分析共纳入了 9 项研究，包括 157 名 HLH 患者、576 名重症登革热患者和 5081 名登革热患者。重症登革热的 HLH 患病率（22.1%，95% CI 8.07 至 48.0%）明显高于登革热的患病率（3.12%，95% CI 0.37 至 21.9%）。与成人（19.0%，95% CI 3.0 至 63.9%）相比，重症登革热患儿的 HLH 患病率更高（22.8%，95% CI 3.9 至 68.4%）。总死亡率为 20.2%（95% CI 9.7 至 37.2%）：结论：登革热相关性HLH在登革热患者中发病率较低，但在重症登革热患者中发病率明显较高，死亡率也较高。
Prevalence and mortality of haemophagocytic lymphohistiocytosis in dengue fever: a systematic review and meta-analysis.
Background: Haemophagocytic lymphohistiocytosis (HLH) is a rare complication of dengue fever with potentially life-threatening consequences and high mortality. Therefore, this study aims to investigate the prevalence, management and outcome of HLH in dengue fever.
Methods: The major electronic databases, including PubMed, ScienceDirect and Ovid SP, were searched from inception until 31 January 2024 to identify relevant studies. Pooled prevalence and mortality were calculated using the random-effects generic inverse variance model with a 95% CI. All the statistical analysis was conducted using R programming.
Results: A total of nine studies with 157 patients with HLH, 576 patients with severe dengue and 5081 patients with dengue fever were included in this meta-analysis. The prevalence of HLH in severe dengue (22.1%, 95% CI 8.07 to 48.0%) was significantly higher than the prevalence in dengue fever (3.12%, 95% CI 0.37 to 21.9%). The prevalence of HLH in severe dengue was higher in the paediatric population (22.8%, 95% CI 3.9 to 68.4%) compared with the adult population (19.0%, 95% CI 3.0 to 63.9%). The overall mortality rate was 20.2% (95% CI 9.7 to 37.2%).
Conclusion: The prevalence of dengue-associated HLH was low in patients with dengue fever but is significantly higher in patients with severe dengue and a high mortality rate.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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