阿尔茨海默病预防和治疗中的不平等。

IF 2.3 Q3 CLINICAL NEUROLOGY
Neurology. Clinical practice Pub Date : 2024-06-01 Epub Date: 2024-04-12 DOI:10.1212/CPJ.0000000000200283
Maurizio Giorelli
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引用次数: 0

摘要

阿尔茨海默病(AD)的发病率在未来几年还会上升,并将成为一种健康和社会紧急状况。预防和治疗阿尔茨海默病的需求在全球范围内仍未得到满足。最近,抗淀粉样蛋白 β 的单克隆抗体(抗 Aβ mAbs)被批准用于治疗老年痴呆症,这增加了如何用药、对谁用药以及用药时间长短的不确定性。对抗 Aβ mAbs 成本效益比的担忧以及对实际风险预防策略的需求进一步加剧了各国医疗保健系统之间的不平等。规划研究以解决正确治疗管理的实际可行性问题、加强风险因素监测方面的国际合作、实施及时诊断的途径以及为全世界的注意力缺失症患者提供有效的医疗和社会支持,对于抗击这一即将到来的流行病将是极其宝贵的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Inequalities in the Prevention and Treatment of Alzheimer Disease.

Incidence of Alzheimer disease (AD) is going to rise in the next years and to become a health and social emergency. The prevention and the therapeutic management of AD still present unmet needs worldwide. The recent approval of monoclonal antibodies against amyloid β (anti-Aβ mAbs) for AD has increased the level of uncertainty regarding on how such drugs should be administered, to whom, and for how long. Concerns about cost-effectiveness ratios of anti-Aβ mAbs and the need for actual strategies of risk prevention have further dug barriers of inequalities between the national health care systems. Planning research to address questions on the real feasibility of the correct therapeutic management, improving international cooperation on surveillance of risk factors, implementing pathways for timely diagnosis, and effective medical and social support for patients with AD worldwide would be extremely valuable to fight against this upcoming pandemic.

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来源期刊
Neurology. Clinical practice
Neurology. Clinical practice CLINICAL NEUROLOGY-
CiteScore
4.00
自引率
0.00%
发文量
77
期刊介绍: Neurology® Genetics is an online open access journal publishing peer-reviewed reports in the field of neurogenetics. The journal publishes original articles in all areas of neurogenetics including rare and common genetic variations, genotype-phenotype correlations, outlier phenotypes as a result of mutations in known disease genes, and genetic variations with a putative link to diseases. Articles include studies reporting on genetic disease risk, pharmacogenomics, and results of gene-based clinical trials (viral, ASO, etc.). Genetically engineered model systems are not a primary focus of Neurology® Genetics, but studies using model systems for treatment trials, including well-powered studies reporting negative results, are welcome.
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