天然 3,4-二氢-2(1H)-喹啉酮--第一部分：植物来源。

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-02-01 DOI:10.1080/14786419.2024.2348667

Shahriar Khadem , Robin J. Marles

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引用次数: 0

摘要

尽管天然产物在药物发现中无疑发挥着举足轻重的作用，但其作为先导化合物的潜力却因可获得性有限和合成过程复杂等挑战而受到阻碍。3,4-二氢-2(1H)-喹啉酮（又称 2-氧代四氢喹啉（2 O-THQ））是众多天然化合物和合成化合物的核心，每种化合物都具有显著的生物特性。本文广泛研究了植物界中 2 O-THQ 生物碱的存在，探讨了它们作为创新生物活性天然产品来源的能力。尽管这些化合物的重要性毋庸置疑，但现有的综述文献尚未对其进行全面的报道，这就凸显了本文在研究其在自然界中的普遍性方面所做出的关键贡献。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Natural 3,4-dihydro-2(1H)-quinolinones- Part I: plant sources

While natural products have undoubtedly played a pivotal role in drug discovery, their potential as lead compounds has been hindered by challenges such as limited accessibility and complex synthesis processes. At the core of numerous natural and synthetic compounds, each exhibiting remarkable biological traits, lies the foundational structure of 3,4-dihydro-2(1H)-quinolinone, also known as 2-oxo-tetrahydroquinoline (2 O-THQ). This article extensively examines the occurrence of 2 O-THQ alkaloids across the plant kingdom, exploring their capacity to serve as a source for innovative bioactive natural products. Despite the undeniable significance of these compounds, the existing body of review literature has yet to provide comprehensive coverage, underscoring the pivotal contribution of this present article in investigating their prevalence in nature.

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.