Akkermansia muciniphila:独立于 2 型免疫的驱虫伴侣。

IF 12.2 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
Gut Microbes Pub Date : 2024-01-01 Epub Date: 2024-05-08 DOI:10.1080/19490976.2024.2338947
Jiaqi Wang, Xiufeng Zhao, Xianhe Li, Xuemin Jin
{"title":"Akkermansia muciniphila:独立于 2 型免疫的驱虫伴侣。","authors":"Jiaqi Wang, Xiufeng Zhao, Xianhe Li, Xuemin Jin","doi":"10.1080/19490976.2024.2338947","DOIUrl":null,"url":null,"abstract":"<p><p>The gut microbiota has coevolved with the host for hundreds of millions of years, playing a beneficial role in host health. Human parasitic helminths are widespread and pose a pervasive global public health issue. Although Type 2 immunity provides partial resistance to helminth infections, the composition of the gut microbiota can change correspondingly. Therefore, it raises the question of what role the gut microbiota plays during helminth infection. <i>Akkermansia muciniphila</i> has emerged as a notable representative of beneficial microorganisms in the gut microbiota. Recent studies indicate that <i>A. muciniphila</i> is not merely associated with helminth infection but is also causally linked to infection. Here, we provide an overview of the crosstalk between <i>A. muciniphila</i> and enteric helminth infection. Our goal is to enhance our understanding of the interplay among <i>A. muciniphila</i>, helminths, and their hosts while also exploring the potential underlying mechanisms.</p>","PeriodicalId":12909,"journal":{"name":"Gut Microbes","volume":"16 1","pages":"2338947"},"PeriodicalIF":12.2000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11086001/pdf/","citationCount":"0","resultStr":"{\"title\":\"<i>Akkermansia muciniphila</i>: a deworming partner independent of type 2 immunity.\",\"authors\":\"Jiaqi Wang, Xiufeng Zhao, Xianhe Li, Xuemin Jin\",\"doi\":\"10.1080/19490976.2024.2338947\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The gut microbiota has coevolved with the host for hundreds of millions of years, playing a beneficial role in host health. Human parasitic helminths are widespread and pose a pervasive global public health issue. Although Type 2 immunity provides partial resistance to helminth infections, the composition of the gut microbiota can change correspondingly. Therefore, it raises the question of what role the gut microbiota plays during helminth infection. <i>Akkermansia muciniphila</i> has emerged as a notable representative of beneficial microorganisms in the gut microbiota. Recent studies indicate that <i>A. muciniphila</i> is not merely associated with helminth infection but is also causally linked to infection. Here, we provide an overview of the crosstalk between <i>A. muciniphila</i> and enteric helminth infection. Our goal is to enhance our understanding of the interplay among <i>A. muciniphila</i>, helminths, and their hosts while also exploring the potential underlying mechanisms.</p>\",\"PeriodicalId\":12909,\"journal\":{\"name\":\"Gut Microbes\",\"volume\":\"16 1\",\"pages\":\"2338947\"},\"PeriodicalIF\":12.2000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11086001/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Gut Microbes\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/19490976.2024.2338947\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/5/8 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"GASTROENTEROLOGY & HEPATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Gut Microbes","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/19490976.2024.2338947","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/5/8 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

数亿年来,肠道微生物群与宿主共同进化,对宿主的健康发挥着有益的作用。人类寄生蠕虫广泛存在,构成了一个普遍的全球公共卫生问题。虽然第二类免疫提供了对蠕虫感染的部分抵抗力,但肠道微生物群的组成也会发生相应的变化。因此,人们不禁要问,在蠕虫感染期间,肠道微生物群究竟扮演着怎样的角色?Akkermansia muciniphila 已成为肠道微生物群中有益微生物的显著代表。最近的研究表明,A. muciniphila 不仅与蠕虫感染有关,还与感染有因果关系。在此,我们将概述粘毛蝇与肠道蠕虫感染之间的相互关系。我们的目标是加深对粘孢子虫、蠕虫及其宿主之间相互作用的理解,同时探索潜在的内在机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Akkermansia muciniphila: a deworming partner independent of type 2 immunity.

The gut microbiota has coevolved with the host for hundreds of millions of years, playing a beneficial role in host health. Human parasitic helminths are widespread and pose a pervasive global public health issue. Although Type 2 immunity provides partial resistance to helminth infections, the composition of the gut microbiota can change correspondingly. Therefore, it raises the question of what role the gut microbiota plays during helminth infection. Akkermansia muciniphila has emerged as a notable representative of beneficial microorganisms in the gut microbiota. Recent studies indicate that A. muciniphila is not merely associated with helminth infection but is also causally linked to infection. Here, we provide an overview of the crosstalk between A. muciniphila and enteric helminth infection. Our goal is to enhance our understanding of the interplay among A. muciniphila, helminths, and their hosts while also exploring the potential underlying mechanisms.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Gut Microbes
Gut Microbes Medicine-Microbiology (medical)
CiteScore
18.20
自引率
3.30%
发文量
196
审稿时长
10 weeks
期刊介绍: The intestinal microbiota plays a crucial role in human physiology, influencing various aspects of health and disease such as nutrition, obesity, brain function, allergic responses, immunity, inflammatory bowel disease, irritable bowel syndrome, cancer development, cardiac disease, liver disease, and more. Gut Microbes serves as a platform for showcasing and discussing state-of-the-art research related to the microorganisms present in the intestine. The journal emphasizes mechanistic and cause-and-effect studies. Additionally, it has a counterpart, Gut Microbes Reports, which places a greater focus on emerging topics and comparative and incremental studies.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信