嗜酸性粒细胞增多症伴多发性洋炎症启动缓解诱导疗法后出现蛛网膜下腔出血并伴有多处脑动脉狭窄：病例报告。

IF 1 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Internal Medicine Pub Date : 2024-12-15 Epub Date: 2024-05-09 DOI:10.2169/internalmedicine.3583-24

Haruka Yasuba, Hirotaka Yamada, Masaya Togo, Kento Matoba, Eriko Yamamoto Kashihara, Keisuke Nishimura, Sho Sendo, Yo Ueda, Jun Saegusa

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引用次数: 0

摘要

我们遇到过一名 64 岁的日本妇女，她在接受嗜酸性粒细胞肉芽肿和多血管炎（EGPA）缓解诱导治疗期间出现蛛网膜下腔出血（SAH）并伴有多处脑动脉狭窄。治疗包括加强类固醇脉冲疗法和持续静脉注射环磷酰胺脉冲疗法，这些疗法产生了良好的效果。鉴于多发性 EGPA 相关脑动脉狭窄和 SAH 的罕见性，将其与其他疾病区分开来至关重要。EGPA 并发颅内出血病变（包括 SAH）的死亡率很高。当 EGPA 发病时出现头痛时，必须考虑 SAH 的可能性。

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Subarachnoid Hemorrhaging with Multiple Cerebral Artery Stenoses after Initiating Remission Induction Therapy for Eosinophilic Granulomatosis with Polyangiitis.

We encountered a 64-year-old Japanese woman who developed subarachnoid hemorrhaging (SAH) with multiple cerebral artery stenoses during remission induction therapy for eosinophilic granulomatosis and polyangiitis (EGPA). The treatment involved intensified steroid pulse therapy and continued intravenous cyclophosphamide pulse therapy, which led to beneficial effects. Given the rarity of multiple EGPA-associated cerebral artery stenoses and SAH, it is crucial to differentiate them from other diseases. The mortality rate of EGPA complicated by intracranial hemorrhagic lesions, including SAH, is high. When headache is present at the onset of EGPA, the possibility of SAH must be considered.

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来源期刊

Internal Medicine 医学-医学：内科

CiteScore

1.90

自引率

8.30%

发文量

审稿时长

2.2 months

期刊介绍： Internal Medicine is an open-access online only journal published monthly by the Japanese Society of Internal Medicine. Articles must be prepared in accordance with "The Uniform Requirements for Manuscripts Submitted to Biomedical Journals (see Annals of Internal Medicine 108: 258-265, 1988), must be contributed solely to the Internal Medicine, and become the property of the Japanese Society of Internal Medicine. Statements contained therein are the responsibility of the author(s). The Society reserves copyright and renewal on all published material and such material may not be reproduced in any form without the written permission of the Society.