来自 Maytenus hookeri 的两种新的齐墩果烷三萜。

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2024-05-08 DOI:10.1080/10286020.2024.2340073

Quan-Yu Yang , Song-Xue Yang , Qiong Wei , Yan-Zi Ma , Bo Li , Xue-Wen Wu , Rui-Han Zhang , Xing-Jie Zhang , Xiao-Li Li , Wei-Lie Xiao

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引用次数: 0

摘要

从 Maytenus hookeri Loes 的茎中分离出了两种新的三萜类化合物 mayteneri A（1）和 mayteneri B（2），以及七种已知化合物（3-9）。通过一维、二维核磁共振、HRESIMS 分析和电子圆二色性（ECD）计算，确定了化合物 1 和 2 的化学结构。已知化合物 3-9 的结构是通过对比其光谱和已报道的光谱确定的。化合物 4-7 对 NLRP3 炎性体具有明显的抑制活性，其 IC50 值为 2.36-3.44 μM。

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Two new oleanane triterpenes from Maytenus hookeri

Two new triterpenes mayteneri A (1), mayteneri B (2), and seven known compounds (3-9) were isolated from stems of Maytenus hookeri Loes. The chemical structures of compounds 1 and 2 were established by 1D, 2D NMR, HRESIMS analysis, and calculating electronic circular dichroism (ECD). The structures of known compounds 3-9 were determined by comparison of their spectral with those reported. Compounds 4-7 showed significant inhibitory activity for NLRP3 inflammasome, with the IC₅₀ values of 2.36–3.44 μM.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.