Vanessa de Abreu Pereira, Adriano Lincoln Albuquerque Mattos, Men de sá Moreira de S. Filho, Pierre Basílio Almeida Fechine
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Regarding the results, the blow-spinning technique made it possible to obtain nanofibers with satisfactory diameters (323–350 nm) and adequate morphology. The addition of Cur resulted in less porous (69–78%), with better mechanical resistance (3.81–6.73 × 10<sup>−2</sup> N mm<sup>−2</sup>), more thermally stable and with lower degree of swelling nanofibers. These conditions favored the release of 75.77–99.98% of Cur. Furthermore, increasing the concentration of Cur improved its antioxidant properties, with values reaching up to 89.11%. Crosslinking occurred through possible electrostatic and hydrogen bond interactions between Cur and Gel molecules (values reached 93.90%). The nanofibers also exhibited good biocompatibility (cellular viability > 70%). 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引用次数: 0
摘要
吹 纺技术可替代电纺丝技术,从含有姜黄素(Cur)的罗非鱼皮中获得明胶(Gel)纳米纤维。利用鱼类废弃物提取凝胶可以通过采用低成本技术获得生物材料,从而为可持续发展做出贡献。因此,通过研究纺丝溶液的粘度以及这些材料的形态、结构、机械、热和抗氧化特性、交联和溶胀程度、孔隙率、体外释放和细胞活力,评估了吹塑纺丝技术获得的纳米纤维以及在这些材料中添加姜黄素的效果。结果表明,吹塑纺丝技术可以获得直径(323-350 纳米)和形态都令人满意的纳米纤维。加入 Cur 后,纳米纤维的多孔性降低(69-78%),机械阻力提高(3.81-6.73 × 10-2 N mm-2),热稳定性提高,膨胀程度降低。这些条件有利于释放 75.77-99.98% 的 Cur。此外,提高 Cur 的浓度还能改善其抗氧化性能,抗氧化值高达 89.11%。Cur和Gel分子之间可能通过静电和氢键相互作用发生交联(值达到93.90%)。纳米纤维还表现出良好的生物相容性(细胞存活率为 70%)。因此,通过吹塑纺丝获得的纳米纤维可作为可持续的、有前途的替代品应用于抗氧化生物钙等领域。
Blow Spinning Technique for Antioxidant Biocuratives from Gelatin–Curcumin-Based Nanofibers
The blow-spinning technique was used as an alternative to electrospinning to obtain gelatin (Gel) nanofibers from Tilapia skins loaded with curcumin (Cur). The use of fish waste to extract Gel makes it possible to contribute to sustainable development by employing a low-cost technique to obtain biomaterials. In this way, the nanofibers obtained by the blow-spinning technique and the effect of adding Cur to these materials were evaluated by studying the viscosity of the spinning solutions and morphology, structure, mechanical, thermal and antioxidant properties, degree of crosslinking and swelling, porosity, in vitro release and cell viability of these materials. Regarding the results, the blow-spinning technique made it possible to obtain nanofibers with satisfactory diameters (323–350 nm) and adequate morphology. The addition of Cur resulted in less porous (69–78%), with better mechanical resistance (3.81–6.73 × 10−2 N mm−2), more thermally stable and with lower degree of swelling nanofibers. These conditions favored the release of 75.77–99.98% of Cur. Furthermore, increasing the concentration of Cur improved its antioxidant properties, with values reaching up to 89.11%. Crosslinking occurred through possible electrostatic and hydrogen bond interactions between Cur and Gel molecules (values reached 93.90%). The nanofibers also exhibited good biocompatibility (cellular viability > 70%). Therefore, it was possible to suggest that the nanofibers obtained by blow spinning can be investigated as sustainable and promising alternatives in applications such as antioxidant biocuratives.
期刊介绍:
-Chemistry of Fiber Materials, Polymer Reactions and Synthesis-
Physical Properties of Fibers, Polymer Blends and Composites-
Fiber Spinning and Textile Processing, Polymer Physics, Morphology-
Colorants and Dyeing, Polymer Analysis and Characterization-
Chemical Aftertreatment of Textiles, Polymer Processing and Rheology-
Textile and Apparel Science, Functional Polymers