The Effect of Taxifolin, a Conjugate of Taxifolin with Glyoxylic Acid, and Naringenin on the Functional Activity of Neutrophils

The aim of this work was to study the effect of taxifolin, a conjugate of taxifolin with glyoxalic acid, and naringenin on the phagocytosis of latex beads by neutrophils and the adhesive properties of these cells. It has been shown that taxifolin did not affect the phagocytic activity and adhesive properties of neutrophils. The conjugate of taxifolin with glyoxylic acid significantly inhibited the phagocytic activity of neutrophils. The conjugate also significantly enhanced the adhesion of these cells. Naringenin reduced the phagocytic activity of neutrophils, however, to a lesser extent than the conjugate. Naringenin also inhibited the adhesion of neutrophils. The data obtained indicate that polyphenols can affect the functional activity of neutrophils; this effect can play an important role in modulating the inflammatory process, in particular when prolonged activation of neutrophils leads to damage of the body’s own cells and tissues.