S. L. Kuznetsov, N. V. Gukasova, I. A. Tubasheva, V. V. Zavarzina, S. V. Aleshin, A. I. Muraveva, A. A. Lapin, V. N. Zelenkov, Yu. I. Poltavets
{"title":"获得并研究含水飞蓟宾的聚合物组合物的抗氧化活性和保肝效果","authors":"S. L. Kuznetsov, N. V. Gukasova, I. A. Tubasheva, V. V. Zavarzina, S. V. Aleshin, A. I. Muraveva, A. A. Lapin, V. N. Zelenkov, Yu. I. Poltavets","doi":"10.1134/S263516762360061X","DOIUrl":null,"url":null,"abstract":"<p>Preparations based on silybin are used as hepatoprotectors in the treatment of liver lesions of various etiologies. The main disadvantage limiting their use is low bioavailability associated with the low solubility of silybin in water. To solve this problem, numerous delivery systems are created that increase its solubility, including those based on biodegradable polymers. This study presents a method for producing a polymer composition containing silybin (PCS) based on copolymers of lactic and glycolic acids. The content of the active ingredient in the product is 5%, its entrapment efficiency in particles is more than 90%; the <i>Z</i>-average particle size in an aqueous suspension is about 200 nm, the polydispersity index is less than 0.2, and the zeta potential is from ‒1 to ‒5 mV. The high antioxidant activity of silybin in the polymer composition by galvanostatic coulometry, as well as in the reaction of the nonenzymatic autoxidation of adrenaline, is shown. In an in vivo study on a model of acute toxic hepatitis induced by carbon tetrachloride, the more pronounced hepatoprotective effect of PCS is found compared with free silybin.</p>","PeriodicalId":716,"journal":{"name":"Nanotechnologies in Russia","volume":"18 2 supplement","pages":"S407 - S415"},"PeriodicalIF":0.8000,"publicationDate":"2024-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Obtaining and Studying the Antioxidant Activity and Hepatoprotective Effect of a Polymer Composition Containing Silybin\",\"authors\":\"S. L. Kuznetsov, N. V. Gukasova, I. A. Tubasheva, V. V. Zavarzina, S. V. Aleshin, A. I. Muraveva, A. A. Lapin, V. N. Zelenkov, Yu. I. Poltavets\",\"doi\":\"10.1134/S263516762360061X\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Preparations based on silybin are used as hepatoprotectors in the treatment of liver lesions of various etiologies. The main disadvantage limiting their use is low bioavailability associated with the low solubility of silybin in water. To solve this problem, numerous delivery systems are created that increase its solubility, including those based on biodegradable polymers. This study presents a method for producing a polymer composition containing silybin (PCS) based on copolymers of lactic and glycolic acids. The content of the active ingredient in the product is 5%, its entrapment efficiency in particles is more than 90%; the <i>Z</i>-average particle size in an aqueous suspension is about 200 nm, the polydispersity index is less than 0.2, and the zeta potential is from ‒1 to ‒5 mV. The high antioxidant activity of silybin in the polymer composition by galvanostatic coulometry, as well as in the reaction of the nonenzymatic autoxidation of adrenaline, is shown. In an in vivo study on a model of acute toxic hepatitis induced by carbon tetrachloride, the more pronounced hepatoprotective effect of PCS is found compared with free silybin.</p>\",\"PeriodicalId\":716,\"journal\":{\"name\":\"Nanotechnologies in Russia\",\"volume\":\"18 2 supplement\",\"pages\":\"S407 - S415\"},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2024-03-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nanotechnologies in Russia\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://link.springer.com/article/10.1134/S263516762360061X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Engineering\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nanotechnologies in Russia","FirstCategoryId":"1085","ListUrlMain":"https://link.springer.com/article/10.1134/S263516762360061X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Engineering","Score":null,"Total":0}
Obtaining and Studying the Antioxidant Activity and Hepatoprotective Effect of a Polymer Composition Containing Silybin
Preparations based on silybin are used as hepatoprotectors in the treatment of liver lesions of various etiologies. The main disadvantage limiting their use is low bioavailability associated with the low solubility of silybin in water. To solve this problem, numerous delivery systems are created that increase its solubility, including those based on biodegradable polymers. This study presents a method for producing a polymer composition containing silybin (PCS) based on copolymers of lactic and glycolic acids. The content of the active ingredient in the product is 5%, its entrapment efficiency in particles is more than 90%; the Z-average particle size in an aqueous suspension is about 200 nm, the polydispersity index is less than 0.2, and the zeta potential is from ‒1 to ‒5 mV. The high antioxidant activity of silybin in the polymer composition by galvanostatic coulometry, as well as in the reaction of the nonenzymatic autoxidation of adrenaline, is shown. In an in vivo study on a model of acute toxic hepatitis induced by carbon tetrachloride, the more pronounced hepatoprotective effect of PCS is found compared with free silybin.
期刊介绍：
Nanobiotechnology Reports publishes interdisciplinary research articles on fundamental aspects of the structure and properties of nanoscale objects and nanomaterials, polymeric and bioorganic molecules, and supramolecular and biohybrid complexes, as well as articles that discuss technologies for their preparation and processing, and practical implementation of products, devices, and nature-like systems based on them. The journal publishes original articles and reviews that meet the highest scientific quality standards in the following areas of science and technology studies: self-organizing structures and nanoassemblies; nanostructures, including nanotubes; functional and structural nanomaterials; polymeric, bioorganic, and hybrid nanomaterials; devices and products based on nanomaterials and nanotechnology; nanobiology and genetics, and omics technologies; nanobiomedicine and nanopharmaceutics; nanoelectronics and neuromorphic computing systems; neurocognitive systems and technologies; nanophotonics; natural science methods in a study of cultural heritage items; metrology, standardization, and monitoring in nanotechnology.
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