转录调控中的非特异性相互作用与转录凝聚体的组织

IF 2.3 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemistry (Moscow) Pub Date : 2024-05-06 DOI:10.1134/S0006297924040084

Anna A. Valyaeva, Eugene V. Sheval

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引用次数: 0

摘要

摘要真核细胞的特点是其内部内容物高度分隔，这确保了细胞内过程的精确和受控调节。在许多过程中，包括转录的不同阶段，都会形成被称为生物分子凝聚体的动态无膜隔室。转录凝聚体包含各种转录因子和 RNA 聚合酶，由蛋白质、DNA 和附近 RNA 之间的高特异性和低特异性相互作用形成。本综述讨论了最近的一些数据，这些数据表明非特异性多价蛋白质-蛋白质和 RNA-蛋白质相互作用在转录的组织和调控中发挥着重要作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Nonspecific Interactions in Transcription Regulation and Organization of Transcriptional Condensates

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Nonspecific Interactions in Transcription Regulation and Organization of Transcriptional Condensates

Eukaryotic cells are characterized by a high degree of compartmentalization of their internal contents, which ensures precise and controlled regulation of intracellular processes. During many processes, including different stages of transcription, dynamic membraneless compartments termed biomolecular condensates are formed. Transcription condensates contain various transcription factors and RNA polymerase and are formed by high- and low-specificity interactions between the proteins, DNA, and nearby RNA. This review discusses recent data demonstrating important role of nonspecific multivalent protein–protein and RNA–protein interactions in organization and regulation of transcription.

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来源期刊

Biochemistry (Moscow) 生物-生化与分子生物学

CiteScore

4.70

自引率

3.60%

发文量

139

审稿时长

2 months

期刊介绍： Biochemistry (Moscow) is the journal that includes research papers in all fields of biochemistry as well as biochemical aspects of molecular biology, bioorganic chemistry, microbiology, immunology, physiology, and biomedical sciences. Coverage also extends to new experimental methods in biochemistry, theoretical contributions of biochemical importance, reviews of contemporary biochemical topics, and mini-reviews (News in Biochemistry).