治疗 COVID-19 感染后疲劳的传统、补充和综合疗法:随机对照试验的系统回顾

IF 2.8 4区 医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE
Xiao-ying Chen , Chun-li Lu , Qian-yun Wang , Xing-ru Pan , Yang-yang Zhang , Jia-le Wang , Jun-Ya Liao , Nai-chong Hu , Chen-yang Wang , Bing-jie Duan , Xue-han Liu , Xin-yan Jin , Jennifer Hunter , Jian-ping Liu
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引用次数: 0

摘要

背景慢性疲劳是COVID-19感染后(或称长COVID)的主要症状。我们的目的是评估传统、补充和整合医学(TCIM)治疗 COVID-19 感染后疲劳的有效性和安全性。方法检索了十个中英文数据库和灰色文献(截至 2023 年 4 月 12 日),以寻找随机对照试验(RCT)。采用 Cochrane "偏倚风险"(RoB)工具。采用建议评估、发展和评价分级法(GRADE)评估证据的确定性。疗效估计值以风险比(RR)或平均差(MD)表示,并附有 95% 的置信区间(CI)。其中一项研究显示,布飞藿香正气胶囊可降低疲劳(n=129,MD -14.90,95%CI -24.53~-5.27);一项研究报告,鲁丹参滴丸可降低疲劳(n=184,MD -1.90,95%CI -2.38~-1.42);另一项研究显示,鲁丹参滴丸的疲劳消失率更高(n=184,RR 4.19,95%CI 2.06~8.53)。与单独使用中药康复治疗相比,一项研究表明,清金益气颗粒加中药康复治疗的疲劳症状较低(n=388,MD -0.48,95%CI -0.50至-0.46)。由于存在RoB和/或不精确的问题,该证据的确定性较低至很低。结论有限的证据表明,各种 TCIM 干预措施可以减轻 COVID-19 后的疲劳。研究注册本综述的方案已在 PROSPERO 注册:CRD42022384136。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Traditional, complementary and integrative medicine for fatigue post COVID-19 infection: A systematic review of randomized controlled trials

Background

Chronic fatigue is a predominant symptom of post COVID-19 condition, or long COVID. We aimed to evaluate the efficacy and safety of Traditional, Complementary and Integrative Medicine (TCIM) for fatigue post COVID-19 infection.

Methods

Ten English and Chinese language databases and grey literature were searched up to 12 April 2023 for randomized controlled trials (RCTs). Cochrane “Risk of bias” (RoB) tool was applied. Evidence certainty was assessed using Grading of Recommendations Assessment, Development, and Evaluation (GRADE). Effect estimates were presented as risk ratio (RR) or mean difference (MD) with 95% confidence interval (CI).

Results

Thirteen RCTs with 1632 participants were included. One RCT showed that Bufei Huoxue herbal capsules reduced fatigue (n=129, MD -14.90, 95%CI -24.53 to -5.27), one RCT reported that Ludangshen herbal liquid lowered fatigue (n=184, MD -1.90, 95%CI -2.38 to -1.42), and the other one RCT shown that fatigue disappearance rate was higher with Ludangshen herbal liquid (n=184, RR 4.19, 95%CI 2.06 to 8.53). Compared to traditional Chinese medicine rehabilitation (TCM-rahab) alone, one RCT showed that fatigue symptoms were lower following Qingjin Yiqi granules plus TCM-rehab (n=388, MD -0.48, 95%CI -0.50 to -0.46). Due to concerns with RoB and/or imprecision, the certainty in this evidence was low to very low. No serious adverse events was reported.

Conclusions

Limited evidence suggests that various TCIM interventions might reduce post COVID-19 fatigue. Larger, high quality RCTs of longer duration are required to confirm these preliminary findings.

Study Registration

The protocol of this review has been registered at PROSPERO: CRD42022384136.

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来源期刊
Integrative Medicine Research
Integrative Medicine Research Medicine-Complementary and Alternative Medicine
CiteScore
6.50
自引率
2.90%
发文量
65
审稿时长
12 weeks
期刊介绍: Integrative Medicine Research (IMR) is a quarterly, peer-reviewed journal focused on scientific research for integrative medicine including traditional medicine (emphasis on acupuncture and herbal medicine), complementary and alternative medicine, and systems medicine. The journal includes papers on basic research, clinical research, methodology, theory, computational analysis and modelling, topical reviews, medical history, education and policy based on physiology, pathology, diagnosis and the systems approach in the field of integrative medicine.
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