病毒感染细胞的早期信号通路

IF 5.7 2区医学 Q1 VIROLOGY

Current opinion in virology Pub Date : 2024-05-07 DOI:10.1016/j.coviro.2024.101411

Delphine Bonhomme, Enzo Z Poirier

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引用次数: 0

摘要

病毒感染会激活特定的模式识别受体和免疫信号转导，导致促炎细胞因子的产生和先天免疫的激活。我们在此描述了病毒识别下游早期信号通路的分子组织，包括构象变化、翻译后修饰、寡聚体的形成以及小分子第二信使的产生。这种分子组织结构可对免疫信号转导进行严格调控，其特点是反应迅速但短暂、非线性和信号放大。基因组突变导致的早期免疫信号转导病理现象说明了免疫信号转导级联的精细调控。

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Early signaling pathways in virus-infected cells

Virus infection activates specific pattern recognition receptors and immune signal transduction, resulting in pro-inflammatory cytokine production and activation of innate immunity. We describe here the molecular organization of early signaling pathways downstream of viral recognition, including conformational changes, post-translational modifications, formation of oligomers, and generation of small-molecule second messengers. Such molecular organization allows tight regulation of immune signal transduction, characterized by swift but transient responses, nonlinearity, and signal amplification. Pathologies of early immune signaling caused by genomic mutations illustrate the fine regulation of the immune transduction cascade.

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来源期刊

Current opinion in virology VIROLOGY-

CiteScore

11.80

自引率

5.10%

发文量

审稿时长

83 days

期刊介绍： Current Opinion in Virology (COVIRO) is a systematic review journal that aims to provide specialists with a unique and educational platform to keep up to date with the expanding volume of information published in the field of virology. It publishes 6 issues per year covering the following 11 sections, each of which is reviewed once a year: Emerging viruses: interspecies transmission; Viral immunology; Viral pathogenesis; Preventive and therapeutic vaccines; Antiviral strategies; Virus structure and expression; Animal models for viral diseases; Engineering for viral resistance; Viruses and cancer; Virus vector interactions. There is also a section that changes every year to reflect hot topics in the field.