Author Nan Lang , Yuan Zhong , Wenkun Lei , Yiwen Xiao , Yaming Hang , Ya Xie , Zhangwei Lv , Yumin Zhang , Xinyao Liu , Minlu Liang , Congjie Zhang , Pei Zhang , Hua Yang , Yun Wu , Qiuyu Wang , Kun Yang , Jing Long , Yuan Liu , Suhong Wang , Yibin Tang , Chun Wang
{"title":"非自杀性自伤患者非适应性认知情绪调节的神经机制。","authors":"Author Nan Lang , Yuan Zhong , Wenkun Lei , Yiwen Xiao , Yaming Hang , Ya Xie , Zhangwei Lv , Yumin Zhang , Xinyao Liu , Minlu Liang , Congjie Zhang , Pei Zhang , Hua Yang , Yun Wu , Qiuyu Wang , Kun Yang , Jing Long , Yuan Liu , Suhong Wang , Yibin Tang , Chun Wang","doi":"10.1016/j.comppsych.2024.152487","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>The incidence of non-suicidal self-injury (NSSI) has been on the rise in recent years. Studies have shown that people with NSSI have difficulties in emotion regulation and cognitive control. In addition, some studies have investigated the cognitive emotion regulation of people with NSSI which found that they have difficulties in cognitive emotion regulation, but there was a lack of research on cognitive emotion regulation strategies and related neural mechanisms.</p></div><div><h3>Methods</h3><p>This study included 117 people with NSSI (age = 19.47 ± 5.13, male = 17) and 84 non-NSSI participants (age = 19.86 ± 4.14, male = 16). People with NSSI met the DSM-5 diagnostic criteria, and non-NSSI participants had no mental or physical disorders. The study collected all participants' data of Cognitive Emotion Regulation Questionnaire (CERQ) and functional magnetic resonance imaging (fMRI) to explore the differences in psychological performance and brain between two groups. Afterwards, Machine learning was used to select the found differential brain regions to obtain the highest correlation regions with NSSI. Then, Allen's Human Brain Atlas database was used to compare with the information on the abnormal brain regions of people with NSSI to find the genetic information related to NSSI. In addition, gene enrichment analysis was carried out to find the related pathways and specific cells that may have differences.</p></div><div><h3>Results</h3><p>The differences between NSSI participants and non-NSSI participants were as follows: positive refocusing (<em>t</em> = −4.74, <em>p</em> < 0.01); refocusing on plans (<em>t</em> = −4.11, <em>p</em> < 0.01); positive reappraisal (<em>t</em> = −9.22, <em>p</em> < 0.01); self-blame (<em>t</em> = 6.30, <em>p</em> < 0.01); rumination (<em>t</em> = 3.64, <em>p</em> < 0.01); catastrophizing (<em>t</em> = 9.10, <em>p</em> < 0.01), and blaming others (<em>t</em> = 2.52, <em>p</em> < 0.01), the precentral gyrus (<em>t</em> = 6.04, <em>p</em><sub>FDR</sub> < 0.05) and the rolandic operculum (<em>t</em> = −4.57, <em>p</em><sub>FDR</sub> < 0.05). Rolandic operculum activity was negatively correlated with blaming others (<em>r</em> = −0.20, <em>p</em> < 0.05). Epigenetic results showed that excitatory neurons (<em>p</em> < 0.01) and inhibitory neurons (<em>p</em> < 0.01) were significant differences in two pathways, “trans-synaptic signaling” (<em>p</em> < −log10<sup>8</sup>) and “modulation of chemical synaptic transmission” (<em>p</em> < −log10<sup>8</sup>) in both cells.</p></div><div><h3>Conclusions</h3><p>People with NSSI are more inclined to adopt non-adaptive cognitive emotion regulation strategies. Rolandic operculum is also abnormally active. Abnormal changes in the rolandic operculum of them are associated with non-adaptive cognitive emotion regulation strategies. Changes in the excitatory and inhibitory neurons provide hints to explore the abnormalities of the neurological mechanisms at the cellular level of them.</p><p>Trial registration number <span>NCT04094623</span><svg><path></path></svg></p></div>","PeriodicalId":10554,"journal":{"name":"Comprehensive psychiatry","volume":"133 ","pages":"Article 152487"},"PeriodicalIF":4.3000,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0010440X24000385/pdfft?md5=1e67996ef8bc6fdb3dabb4af4584c90f&pid=1-s2.0-S0010440X24000385-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Neural mechanism of non-adaptive cognitive emotion regulation in patients with non-suicidal self-injury\",\"authors\":\"Author Nan Lang , Yuan Zhong , Wenkun Lei , Yiwen Xiao , Yaming Hang , Ya Xie , Zhangwei Lv , Yumin Zhang , Xinyao Liu , Minlu Liang , Congjie Zhang , Pei Zhang , Hua Yang , Yun Wu , Qiuyu Wang , Kun Yang , Jing Long , Yuan Liu , Suhong Wang , Yibin Tang , Chun Wang\",\"doi\":\"10.1016/j.comppsych.2024.152487\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>The incidence of non-suicidal self-injury (NSSI) has been on the rise in recent years. Studies have shown that people with NSSI have difficulties in emotion regulation and cognitive control. In addition, some studies have investigated the cognitive emotion regulation of people with NSSI which found that they have difficulties in cognitive emotion regulation, but there was a lack of research on cognitive emotion regulation strategies and related neural mechanisms.</p></div><div><h3>Methods</h3><p>This study included 117 people with NSSI (age = 19.47 ± 5.13, male = 17) and 84 non-NSSI participants (age = 19.86 ± 4.14, male = 16). People with NSSI met the DSM-5 diagnostic criteria, and non-NSSI participants had no mental or physical disorders. The study collected all participants' data of Cognitive Emotion Regulation Questionnaire (CERQ) and functional magnetic resonance imaging (fMRI) to explore the differences in psychological performance and brain between two groups. Afterwards, Machine learning was used to select the found differential brain regions to obtain the highest correlation regions with NSSI. Then, Allen's Human Brain Atlas database was used to compare with the information on the abnormal brain regions of people with NSSI to find the genetic information related to NSSI. In addition, gene enrichment analysis was carried out to find the related pathways and specific cells that may have differences.</p></div><div><h3>Results</h3><p>The differences between NSSI participants and non-NSSI participants were as follows: positive refocusing (<em>t</em> = −4.74, <em>p</em> < 0.01); refocusing on plans (<em>t</em> = −4.11, <em>p</em> < 0.01); positive reappraisal (<em>t</em> = −9.22, <em>p</em> < 0.01); self-blame (<em>t</em> = 6.30, <em>p</em> < 0.01); rumination (<em>t</em> = 3.64, <em>p</em> < 0.01); catastrophizing (<em>t</em> = 9.10, <em>p</em> < 0.01), and blaming others (<em>t</em> = 2.52, <em>p</em> < 0.01), the precentral gyrus (<em>t</em> = 6.04, <em>p</em><sub>FDR</sub> < 0.05) and the rolandic operculum (<em>t</em> = −4.57, <em>p</em><sub>FDR</sub> < 0.05). Rolandic operculum activity was negatively correlated with blaming others (<em>r</em> = −0.20, <em>p</em> < 0.05). Epigenetic results showed that excitatory neurons (<em>p</em> < 0.01) and inhibitory neurons (<em>p</em> < 0.01) were significant differences in two pathways, “trans-synaptic signaling” (<em>p</em> < −log10<sup>8</sup>) and “modulation of chemical synaptic transmission” (<em>p</em> < −log10<sup>8</sup>) in both cells.</p></div><div><h3>Conclusions</h3><p>People with NSSI are more inclined to adopt non-adaptive cognitive emotion regulation strategies. Rolandic operculum is also abnormally active. Abnormal changes in the rolandic operculum of them are associated with non-adaptive cognitive emotion regulation strategies. Changes in the excitatory and inhibitory neurons provide hints to explore the abnormalities of the neurological mechanisms at the cellular level of them.</p><p>Trial registration number <span>NCT04094623</span><svg><path></path></svg></p></div>\",\"PeriodicalId\":10554,\"journal\":{\"name\":\"Comprehensive psychiatry\",\"volume\":\"133 \",\"pages\":\"Article 152487\"},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2024-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S0010440X24000385/pdfft?md5=1e67996ef8bc6fdb3dabb4af4584c90f&pid=1-s2.0-S0010440X24000385-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Comprehensive psychiatry\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0010440X24000385\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PSYCHIATRY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Comprehensive psychiatry","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0010440X24000385","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}
Neural mechanism of non-adaptive cognitive emotion regulation in patients with non-suicidal self-injury
Background
The incidence of non-suicidal self-injury (NSSI) has been on the rise in recent years. Studies have shown that people with NSSI have difficulties in emotion regulation and cognitive control. In addition, some studies have investigated the cognitive emotion regulation of people with NSSI which found that they have difficulties in cognitive emotion regulation, but there was a lack of research on cognitive emotion regulation strategies and related neural mechanisms.
Methods
This study included 117 people with NSSI (age = 19.47 ± 5.13, male = 17) and 84 non-NSSI participants (age = 19.86 ± 4.14, male = 16). People with NSSI met the DSM-5 diagnostic criteria, and non-NSSI participants had no mental or physical disorders. The study collected all participants' data of Cognitive Emotion Regulation Questionnaire (CERQ) and functional magnetic resonance imaging (fMRI) to explore the differences in psychological performance and brain between two groups. Afterwards, Machine learning was used to select the found differential brain regions to obtain the highest correlation regions with NSSI. Then, Allen's Human Brain Atlas database was used to compare with the information on the abnormal brain regions of people with NSSI to find the genetic information related to NSSI. In addition, gene enrichment analysis was carried out to find the related pathways and specific cells that may have differences.
Results
The differences between NSSI participants and non-NSSI participants were as follows: positive refocusing (t = −4.74, p < 0.01); refocusing on plans (t = −4.11, p < 0.01); positive reappraisal (t = −9.22, p < 0.01); self-blame (t = 6.30, p < 0.01); rumination (t = 3.64, p < 0.01); catastrophizing (t = 9.10, p < 0.01), and blaming others (t = 2.52, p < 0.01), the precentral gyrus (t = 6.04, pFDR < 0.05) and the rolandic operculum (t = −4.57, pFDR < 0.05). Rolandic operculum activity was negatively correlated with blaming others (r = −0.20, p < 0.05). Epigenetic results showed that excitatory neurons (p < 0.01) and inhibitory neurons (p < 0.01) were significant differences in two pathways, “trans-synaptic signaling” (p < −log108) and “modulation of chemical synaptic transmission” (p < −log108) in both cells.
Conclusions
People with NSSI are more inclined to adopt non-adaptive cognitive emotion regulation strategies. Rolandic operculum is also abnormally active. Abnormal changes in the rolandic operculum of them are associated with non-adaptive cognitive emotion regulation strategies. Changes in the excitatory and inhibitory neurons provide hints to explore the abnormalities of the neurological mechanisms at the cellular level of them.
期刊介绍：
"Comprehensive Psychiatry" is an open access, peer-reviewed journal dedicated to the field of psychiatry and mental health. Its primary mission is to share the latest advancements in knowledge to enhance patient care and deepen the understanding of mental illnesses. The journal is supported by a diverse team of international editors and peer reviewers, ensuring the publication of high-quality research with a strong focus on clinical relevance and the implications for psychopathology.
"Comprehensive Psychiatry" encourages authors to present their research in an accessible manner, facilitating engagement with clinicians, policymakers, and the broader public. By embracing an open access policy, the journal aims to maximize the global impact of its content, making it readily available to a wide audience and fostering scientific collaboration and public awareness beyond the traditional academic community. This approach is designed to promote a more inclusive and informed dialogue on mental health, contributing to the overall progress in the field.
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