从形态到分子:非小细胞肺癌多原发肺癌与肺内转移瘤的鉴别进展。

IF 8.3 2区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY
ACS Applied Materials & Interfaces Pub Date : 2024-09-01 Epub Date: 2024-05-08 DOI:10.1097/PAP.0000000000000449
Gheorghe-Emilian Olteanu, Izidor Kern, Lipika Kalson, Luka Brcic
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引用次数: 0

摘要

多发性肺结节的发病率越来越高,这凸显了精确区分多发性原发性肺癌(MPLC)和肺内转移瘤(IPM)的必要性。这种区分会影响患者的预后和治疗策略。多发性肺结节的发病率从19.7%到55.5%不等,凸显了这一挑战的临床意义。从历史上看,组织病理学,尤其是综合组织学评估(CHA)在区分 MPLC 和 IPM 方面发挥了关键作用。然而,组织病理学评估有很大的局限性,因此需要不断寻找更好的方法来区分这些病变。区分 MPLC 和 IPM 的最佳策略是结合临床数据、放射学、组织学和分子方法的多学科方法。组织学可提供结构和细胞特征,放射学可提供解剖背景和病变特征,分子方法可揭示对准确区分至关重要的分子特征。结合临床数据可进一步提高诊断的精确性。本综述介绍了目前对多发性肺肿瘤的认识和方法。显然,即使结合病理学、放射学和分子数据,也不一定能对多灶性肺肿瘤进行明确分类。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
From Morphology to Molecules: Advances in the Distinction of Multiple Primary Lung Cancers From Intrapulmonary Metastases in Non-Small Cell Lung Cancer.

The increasing incidence of multiple lung nodules underscores the need for precise differentiation between multiple primary lung cancers (MPLCs) and intrapulmonary metastases (IPMs). This distinction impacts patient prognosis and treatment strategies. The prevalence of multiple lung nodules, ranging from 19.7% to 55.5%, highlights the clinical significance of this challenge. Historically, the role of histopathology, particularly comprehensive histology assessment (CHA), has been pivotal in differentiating MPLCs and IPMs. However, CHA has significant limitations, resulting in a constant search for a better way to distinguish those lesions. The best strategy for delineating MPLCs from IPMs is a multidisciplinary approach combining clinical data, radiology, histology, and molecular methods. Histology provides architectural and cellular characteristics, radiology contributes anatomic context and lesion characterization, and molecular methods reveal molecular features critical for accurate differentiation. Incorporating clinical data further enhances diagnostic precision. This review presents current knowledge and current approaches to multiple lung tumors. It is clear that even with a combination of pathology, radiology, and molecular data, definitive classification of multifocal lung tumors is not always possible.

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来源期刊
ACS Applied Materials & Interfaces
ACS Applied Materials & Interfaces 工程技术-材料科学:综合
CiteScore
16.00
自引率
6.30%
发文量
4978
审稿时长
1.8 months
期刊介绍: ACS Applied Materials & Interfaces is a leading interdisciplinary journal that brings together chemists, engineers, physicists, and biologists to explore the development and utilization of newly-discovered materials and interfacial processes for specific applications. Our journal has experienced remarkable growth since its establishment in 2009, both in terms of the number of articles published and the impact of the research showcased. We are proud to foster a truly global community, with the majority of published articles originating from outside the United States, reflecting the rapid growth of applied research worldwide.
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