高血压、血管紧张素转换酶抑制剂与高龄老人运动表现之间的关系:ilSIRENTE研究的结果。

IF 3.3 Q2 GERIATRICS & GERONTOLOGY
H J Coelho-Junior, R Calvani, M Tosato, A Álvarez-Bustos, F Landi, A Picca, E Marzetti
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引用次数: 0

摘要

背景:有关老年人高血压相关参数与体能表现之间关系的研究结果相互矛盾。这些不同结果的一个可能解释是,调查可能没有根据血管紧张素转换酶抑制剂(ACEI)的使用情况调整其分析:目的:研究高血压相关参数、血管紧张素转换酶抑制剂的使用以及一系列老年人体能测试之间的关系:设计:通过ilSIRENTE数据库进行横断面研究:背景:Sirente 地区的山区社区(意大利阿布鲁佐拉奎拉):所有在 1924 年 1 月 1 日前出生在 Sirente 地区(13 个市镇)且在研究时居住在该地区的人都被确认并邀请参加。最终样本包括 364 名老年人(平均年龄:85.8 ± 标准差 [SD] 4.8):通过等长手握强度(IHG)、正常和快步行走速度(WS)、5 次坐立测试(5STS)和肌肉力量测量来评估身体表现。休息 20-40 分钟后测量血压(BP),参与者保持直立坐姿。药物根据解剖治疗和化学代码进行编码。ACEI分为中枢作用型(ACEI-c)和外周作用型(ACEI-p)。检测了血液炎症指标、游离胰岛素样生长因子 1(IGF-1)和 IGF 结合蛋白 3(IGFBP-3):结果:结果表明,5STS 测试与舒张压值呈显著负相关。然而,根据 ACEI 的使用情况进行调整后,其显著性消失。服用 ACEI 的参与者比未服用 ACEI 的参与者更有可能拥有更强的特定肌肉力量和更高的血液 IGFBP-3 水平。根据 ACEI 亚型对参与者进行分类后,与 ACEI-c 使用者相比,ACEI-p 使用者的血液 IGF-1 水平更高:本研究的主要结果表明,ACEI 的使用可能会影响老年人高血压相关参数与神经肌肉参数之间的联系。这些结果可能与 ACEI-p 对 IGF-1 通路的影响有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Associations Between Hypertension, Angiotensin-Converting Enzyme Inhibitors, and Physical Performance in Very Old Adults: Results from the ilSIRENTE Study.

Background: Results regarding the associations between hypertension-related parameters and physical performance in older adults are conflicting. A possible explanation for these divergent results is that investigations may not have adjusted their analyses according to the use of angiotensin-converting enzyme inhibitors (ACEIs).

Objectives: To examine the associations between hypertension-related parameters, ACEI use, and a set of physical performance tests in very old adults.

Design: Cross-sectional study from the ilSIRENTE database.

Setting: Mountain community of the Sirente geographic area (L'Aquila, Abruzzo, Italy).

Participants: All persons born in the Sirente area (13 municipalities) before 1 January 1924 and living in that region at the time of study were identified and invited to participate. The final sample included 364 older adults (mean age: 85.8 ± standard deviation [SD] 4.8).

Measurements: Physical performance was assessed using isometric handgrip strength (IHG), walking speed (WS) at normal and fast pace, 5-time sit-to-stand test (5STS), and muscle power measures. Blood pressure (BP) was measured after 20 to 40 min of rest, while participants sat in an upright position. Drugs were coded according to the Anatomical Therapeutic and Chemical codes. ACEIs were categorized in centrally (ACEI-c) and peripherally (ACEI-p) acting. Blood inflammatory markers, free insulin-like growth factor 1 (IGF-1), and IGF-binding protein 3 (IGFBP-3) were assayed.

Results: Results indicated that 5STS test was significantly and negatively associated with diastolic BP values. However, significance was lost when results were adjusted for ACEI use. Participants on ACEIs were more likely to have greater specific muscle power and higher blood levels of IGFBP-3 than non-ACEI users. When participants were categorized according to ACEI subtypes, those on ACEI-p had higher blood IGF-1 levels compared with ACEI-c users.

Conclusions: The main findings of the present study indicate that ACEI use might influence the association between hypertension-related parameters and neuromuscular parameters in very old adults. Such results may possibly be linked to the effects of ACEI-p on the IGF-1 pathway.

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来源期刊
Journal of Frailty & Aging
Journal of Frailty & Aging GERIATRICS & GERONTOLOGY-
CiteScore
5.90
自引率
7.70%
发文量
54
期刊介绍: The Journal of Frailty & Aging is a peer-reviewed international journal aimed at presenting articles that are related to research in the area of aging and age-related (sub)clinical conditions. In particular, the journal publishes high-quality papers describing and discussing social, biological, and clinical features underlying the onset and development of frailty in older persons.          The Journal of Frailty & Aging is composed by five different sections: - Biology of frailty and aging In this section, the journal presents reports from preclinical studies and experiences focused at identifying, describing, and understanding the subclinical pathophysiological mechanisms at the basis of frailty and aging. - Physical frailty and age-related body composition modifications Studies exploring the physical and functional components of frailty are contained in this section. Moreover, since body composition plays a major role in determining physical frailty and, at the same time, represents the most evident feature of the aging process, special attention is given to studies focused on sarcopenia and obesity at older age. - Neurosciences of frailty and aging The section presents results from studies exploring the cognitive and neurological aspects of frailty and age-related conditions. In particular, papers on neurodegenerative conditions of advanced age are welcomed. - Frailty and aging in clinical practice and public health This journal’s section is devoted at presenting studies on clinical issues of frailty and age-related conditions. This multidisciplinary section particularly welcomes reports from clinicians coming from different backgrounds and specialties dealing with the heterogeneous clinical manifestations of advanced age. Moreover, this part of the journal also contains reports on frailty- and age-related social and public health issues. - Clinical trials and therapeutics This final section contains all the manuscripts presenting data on (pharmacological and non-pharmacological) interventions aimed at preventing, delaying, or treating frailty and age-related conditions.The Journal of Frailty & Aging is a quarterly publication of original papers, review articles, case reports, controversies, letters to the Editor, and book reviews. Manuscripts will be evaluated by the editorial staff and, if suitable, by expert reviewers assigned by the editors. The journal particularly welcomes papers by researchers from different backgrounds and specialities who may want to share their views and experiences on the common themes of frailty and aging.The abstracting and indexing of the Journal of Frailty & Aging is covered by MEDLINE (approval by the National Library of Medicine in February 2016).
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